Colony-stimulating factor-1 exerts direct effects on the proliferation and invasiveness of endometrial epithelial cells.

Colony-stimulating factor-1 exerts direct effects on the proliferation and invasiveness of endometrial epithelial cells.
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DOI:
10.1016/j.fertnstert.2011.03.026
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发表时间:
2011-06-30
影响因子:
6.7
通讯作者:
Tekmal, Rajeshwar Rao
Tekmal, Rajeshwar Rao
中科院分区:
医学2区
文献类型:
--
作者:
Aligeti, Sabitha;Kirma, Nameer B.;Binkley, Peter A.;Schenken, Robert S.;Tekmal, Rajeshwar Rao

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Although macrophage colony stimulating factor (CSF-1) has been suggested to play a role in part in maintaining the chronic inflammatory response in endometriosis, our previous data suggest that CSF-1 may also play a role in early endometriosis lesion formation. In the current studies, we have examined this possibility and have shown that CSF-1, in an autocrine fashion, has a direct effect on endometrial epithelial cell proliferation and attachment to peritoneal mesothelial cells, early steps in endometriosis lesion formation on the peritoneum.
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