Fish consumption, low-level mercury, lipids, and inflammatory markers in children.
Fish consumption, low-level mercury, lipids, and inflammatory markers in children.
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DOI：
10.1016/j.envres.2011.10.002
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发表时间：
2012-01
影响因子：
8.3
通讯作者：
Bendinskas, Kestutis G.
中科院分区：
文献类型：
--
作者：
Gump, Brooks B.;MacKenzie, James A.;Dumas, Amy K.;Palmer, Christopher D.;Parsons, Patrick J.;Segu, Zaneer M.;Mechref, Yehia S.;Bendinskas, Kestutis G.
有大量证据表明，食用鱼类对健康有许多好处，包括降低心血管疾病的风险。然而，鱼类也是人类接触汞（Hg）的主要来源。在一项9-11岁儿童（N = 100）的横断面研究中，我们测量了鱼类消费量、血脂、总血汞、昼夜唾液皮质醇（全天收集4个样本），并使用光谱计数鸟枪蛋白质组学对血清蛋白进行了蛋白质组学分析。与不吃鱼的儿童相比，吃鱼的儿童具有更强的抗动脉粥样硬化血脂谱，但血汞水平更高。虽然这些儿童的血汞水平非常低（M = 0.77微克/升;除1名参与者外，所有参与者的血汞水平均低于3.27微克/升），但血汞升高与昼夜皮质醇水平降低显著相关。血汞也显着相关的急性期蛋白质提示全身炎症，和这些蛋白质中的几个被发现显着减少汞和减少皮质醇之间的关联时，包括在模型中。这项针对儿童人群的研究首次在儿童样本中记录了人类血液汞、全身炎症和内分泌干扰之间的关联。如果不更好地了解动脉粥样硬化保护脂质谱相对于钝性昼夜皮质醇和全身炎症的长期后果，则不可能确定儿童食用鱼类的风险-效益比。
There is considerable evidence that consuming fish has numerous health benefits, including a reduced risk of cardiovascular disease. However, fish is also the primary source of human exposure to mercury (Hg). In a cross-sectional study of 9–11 year old children (N = 100), we measured fish consumption, blood lipids, total blood Hg, diurnal salivary cortisol (4 samples collected throughout the day), and performed a proteomic analysis of serum proteins using spectral count shotgun proteomics. Children that consumed fish had a significantly more atheroprotective lipid profile but higher levels of blood Hg relative to children that did not consume fish. Although the levels of blood Hg were very low in these children (M = 0.77 μg/L; all but 1 participant had levels below 3.27 μg/L), increasing blood Hg was significantly associated with blunted diurnal cortisol levels. Blood Hg was also significantly associated with acute-phase proteins suggesting systemic inflammation, and several of these proteins were found to significantly reduce the association between Hg and diminished cortisol when included in the model. This study of a pediatric population is the first to document an association between blood Hg, systemic inflammation, and endocrine disruption in humans, in a pediatric sample. Without a better understanding of the long-term consequences of an atheroprotective lipid profile relative to blunted diurnal cortisol and systemic inflammation, a determination of the risk-benefit ratio for fish consumption by children is not possible.
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DOI：
10.1080/00039896.1969.10666872
发表时间：
1969-01-01
期刊：
ARCHIVES OF ENVIRONMENTAL HEALTH
影响因子：
--
作者：
ABERG, B;EKMAN, L;SNIHS, JO
通讯作者：
SNIHS, JO
影响因子：
8.3
作者：
Gardner, Renee M.;Nyland, Jennifer F.;Silva, Ines A.;Ventura, Ana Maria;de Souza, Jose Maria;Silbergeld, Ellen K.
通讯作者：
Silbergeld, Ellen K.
影响因子：
2.4
作者：
Franchimont, D;Kino, T;Chrousos, G
通讯作者：
Chrousos, G
影响因子：
4.9
作者：
Hansen, G;Victor, R;Schweitzer, C
通讯作者：
Schweitzer, C
影响因子：
4.9
作者：
Gunnarsdottir, I.;Tomasson, H.;Thorsdottir, I.
通讯作者：
Thorsdottir, I.