Patient self-report for evaluating mild cognitive impairment and prodromal Alzheimer's disease.
Patient self-report for evaluating mild cognitive impairment and prodromal Alzheimer's disease.
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DOI：
10.1186/alzrt97
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发表时间：
2011-12-09
期刊：
影响因子：
--
通讯作者：
Cantillon M
中科院分区：
文献类型：
--
作者：
Frank L;Lenderking WR;Howard K;Cantillon M
患者报告结果（PRO）测量用于评估许多治疗领域的疾病和治疗，捕捉通过临床医生或知情人报告无法获得的疾病的相关方面，包括患者可能比周围人有更高认识的方面。鉴于认知障碍和洞察力丧失的存在，在轻度认知障碍 (MCI) 和前驱阿尔茨海默氏病 (AD) 中使用 PRO 测量会带来挑战。本概述提出了与患者报告价值相关的问题，重点强调了洞察力的作用。日常生活功能和执行功能的复杂活动成为获得患者自我报告的特别有希望的领域。然而，在 MCI 和前驱 AD 中，患者自我报告的全部承诺尚未实现，部分原因是缺乏专门针对轻度疾病开发的 PRO 措施、新措施开发中最佳实践的使用有限以及对心理测量评估的关注有限。解决不同的诊断定义并提高对 MCI 和前驱 AD 的临床理解对于 PRO 措施的开发和使用也至关重要。
Patient-reported outcome (PRO) measures are used to evaluate disease and treatments in many therapeutic areas, capturing relevant aspects of the disorder not obtainable through clinician or informant report, including those for which patients may have a greater level of awareness than those around them. Using PRO measures in mild cognitive impairment (MCI) and prodromal Alzheimer's disease (AD) presents challenges given the presence of cognitive impairment and loss of insight. This overview presents issues relevant to the value of patient report with emphasis on the role of insight. Complex activities of daily living functioning and executive functioning emerge as areas of particular promise for obtaining patient self-report. The full promise of patient self-report has yet to be realized in MCI and prodromal AD, however, in part because of lack of PRO measures developed specifically for mild disease, limited use of best practices in new measure development, and limited attention to psychometric evaluation. Resolving different diagnostic definitions and improving clinical understanding of MCI and prodromal AD will also be critical to the development and use of PRO measures.
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