High levels of hair manganese in children living in the vicinity of a ferro-manganese alloy production plant.
High levels of hair manganese in children living in the vicinity of a ferro-manganese alloy production plant.
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居住在铁 - 曼加纳合金生产厂附近的儿童中的高锰。
DOI：
10.1016/j.neuro.2009.04.005
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发表时间：
2009-11
期刊：
影响因子：
3.4
通讯作者：
Mergler D
中科院分区：
文献类型：
--
作者：
Menezes-Filho JA;Paes CR;Pontes AM;Moreira JC;Sarcinelli PN;Mergler D
锰（Mn）是一种必需元素，但在高浓度下是一种有效的有毒物质。虽然有大量关于职业暴露的文献，但很少有研究对生活在空气中锰的重要来源附近的成人和儿童进行研究。本研究的目的是分析头发锰的儿童生活在附近的铁锰合金生产厂在大萨尔瓦多地区，国家的巴伊亚，巴西和检查因素，影响这个生物指标的曝光。我们检查了109名年龄在1至10岁之间的儿童，他们住在工厂附近。根据与排放源的接近程度和顺风位置，先验地确定了四个独立的住房区。还评价了具有相似社会经济地位的非暴露组（n=43）。用石墨炉原子吸收光谱法（GFAAS）测定人发锰（MnH）含量。还评估了可能的混杂血液学参数。接触组儿童MnH平均浓度为15.20 μg/g（1.10-95.50 μg/g），未接触组为1.37 μg/g（0.39-5.58 μg/g）。前者的MnH浓度分别为7.95±1.40 μg/g（距植物最远处）、11.81±1.11 μg/g（中部）、34.43±8.66 μg/g（距植物最近处）和34.22±9.15 μg/g（正下风向处）。多元回归分析的对数转换MnH浓度的暴露儿童得出一个模型，解释了36.8%的变异性。按重要性排序，儿童居住地、性别（女孩>男孩）和母亲在该地区出生时居住的时间与MnH显著相关。事后分析表明，暴露区域有2个分组，与其他人相比，那些生活在最接近工厂和顺风处的人显示出更高的MnH浓度。母亲在孩子出生前在社区生活的时间对孩子目前MnH的贡献表明，子宫内暴露可能起作用。目前正在对这些儿童的神经行为表现进行锰暴露研究。
Manganese (Mn) is an essential element, but an effective toxic at high concentrations. While there is an extensive literature on occupational exposure, few studies have examined adults and children living near important sources of airborne Mn. The objective of this study was to analyze hair Mn of children living in the vicinity of a ferro-manganese alloy production plant in the Great Salvador region, State of Bahia, Brazil and examine factors that influence this bioindicator of exposure. We examined 109 children in the age range of 1 to 10 years, living near the plant. Four separate housing areas were identified a priori on the bases of proximity to the emission sources and downwind location. A non-exposed group (n=43) of similar socioeconomic status was also evaluated. Mn hair (MnH) concentration was measured by graphite atomic absorption spectrometry (GFAAS). Possible confounding hematological parameters were also assessed. Mean MnH concentration was 15.20 μg/g (1.10–95.50 μg/g) for the exposed children and 1.37 μg/g (0.39–5.58 μg/g) for the non-exposed. For the former, MnH concentrations were 7.95±1.40 μg/g (farthest from the plant), 11.81±1.11 μg/g (mid-region), 34.43±8.66 μg/g (closest to the plant) and 34.22±9.15 μg/g (directly downwind). Multiple regression analysis on log transformed MnH concentrations for the exposed children derived a model that explained 36.8% of the variability. In order of importance, area of children’s residence, gender (girls > boys) and time of mother’s residence in the area at the birth of the child, were significantly associated with MnH. Post hoc analyses indicated 2 groupings for exposure areas, with those living closest to and downwind of the plant displaying higher MnH concentrations compared to the others. The contribution of the time the mother lived in the community prior to the child’s birth to the children’s current MnH suggests that in utero exposure may play a role. A study of neurobehavioral performance with respect to Mn exposure in these children is currently underway.
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影响因子：
3.8
作者：
Brenneman, KA;Wong, BA;Dorman, DC
通讯作者：
Dorman, DC
影响因子：
9.8
作者：
Miekeley, N;Carneiro, MTWD;da Silveira, CLP
通讯作者：
da Silveira, CLP
影响因子：
--
作者：
PAPAVASILIOU, PS;MILLER, ST;COTZIAS, GC
通讯作者：
COTZIAS, GC
影响因子：
9.8
作者：
Rodriguez-Agudelo, Yaneth;Riojas-Rodriguez, Horacio;Santos-Burgoa, Carlos
通讯作者：
Santos-Burgoa, Carlos
影响因子：
3.9
作者：
COLLIPP, PJ;CHEN, SY;MAITINSKY, S
通讯作者：
MAITINSKY, S