Mapping the spatio-temporal structure of motor cortical LFP and spiking activities during reach-to-grasp movements.
Mapping the spatio-temporal structure of motor cortical LFP and spiking activities during reach-to-grasp movements.
复制标题
DOI：
10.3389/fncir.2013.00048
复制
发表时间：
2013
影响因子：
3.5
通讯作者：
Brochier T
中科院分区：
文献类型：
--
作者：
Riehle A;Wirtssohn S;Grün S;Brochier T
抓住一个物体涉及与物体的物理特性相关的手和手指。但是，皮质网络仍然不清楚这些网络的信息是如何处理和集成的。通过使用100电极阵列长期植入猴子运动皮层LFP的100电极阵列，来自人口量度（本地现场电位，LFP）和单个神经元峰值活动的信号同时记录。组成运动相关的电势（MRP）在这里运动，我们表明每个MRP组件的峰值放大器及其相对于运动的潜伏期沿通过比较映射方法覆盖的皮质表面，我们建议MRP的时空结构反映了触及式运动的复杂物理特性。 MRP涉及神经元活性的另外两种措施：每个电极位点的单个神经元峰值活性的临时轮廓和单个神经元活性的体感受感受观察到LFP和峰值活动的空间表示广泛重叠，并且与上肢的近端和盘式表示的空间分布相关，这些数据表明，在运动皮层中，涉及精确的空间周期性激活模式控制覆盖范围的运动，并提供有关运动皮层功能组织在触及和对象操纵过程中的功能组织的一些新见解。
Grasping an object involves shaping the hand and fingers in relation to the object’s physical properties. Following object contact, it also requires a fine adjustment of grasp forces for secure manipulation. Earlier studies suggest that the control of hand shaping and grasp force involve partially segregated motor cortical networks. However, it is still unclear how information originating from these networks is processed and integrated. We addressed this issue by analyzing massively parallel signals from population measures (local field potentials, LFPs) and single neuron spiking activities recorded simultaneously during a delayed reach-to-grasp task, by using a 100-electrode array chronically implanted in monkey motor cortex. Motor cortical LFPs exhibit a large multi-component movement-related potential (MRP) around movement onset. Here, we show that the peak amplitude of each MRP component and its latency with respect to movement onset vary along the cortical surface covered by the array. Using a comparative mapping approach, we suggest that the spatio-temporal structure of the MRP reflects the complex physical properties of the reach-to-grasp movement. In addition, we explored how the spatio-temporal structure of the MRP relates to two other measures of neuronal activity: the temporal profile of single neuron spiking activity at each electrode site and the somatosensory receptive field properties of single neuron activities. We observe that the spatial representations of LFP and spiking activities overlap extensively and relate to the spatial distribution of proximal and distal representations of the upper limb. Altogether, these data show that, in motor cortex, a precise spatio-temporal pattern of activation is involved for the control of reach-to-grasp movements and provide some new insight about the functional organization of motor cortex during reaching and object manipulation.
登录
查看更多内容
影响因子：
2.5
作者：
EVARTS, EV
通讯作者：
EVARTS, EV
影响因子：
2.5
作者：
KWAN, HC;MACKAY, WA;WONG, YC
通讯作者：
WONG, YC
影响因子：
2
作者：
Brochier, T;Boudreau, MJ;Smith, AM
通讯作者：
Smith, AM
影响因子：
5.3
作者：
Kraskov, Alexander;Prabhu, Gita;Brochier, Thomas
通讯作者：
Brochier, Thomas
影响因子：
2.5
作者：
Kilavik, Bjorg Elisabeth;Confais, Joachim;Riehle, Alexa
通讯作者：
Riehle, Alexa