IL-36 cytokines in inflammatory and malignant diseases: not the new kid on the block anymore.
IL-36 cytokines in inflammatory and malignant diseases: not the new kid on the block anymore.
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DOI：
10.1007/s00018-021-03909-4
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发表时间：
2021-09
期刊：
影响因子：
--
通讯作者：
Brint E
中科院分区：
文献类型：
--
作者：
Byrne J;Baker K;Houston A;Brint E
细胞因子的IL-36家族在2000年首次基于它们与IL-1细胞因子的序列同源性被鉴定。在随后的几年中，这些细胞因子激动或拮抗IL-1 R同源物（现在称为IL-36受体（IL-36 R））的能力被鉴定出来，这些细胞因子经历了几个周期的重新命名，目前的命名法在2010年提出。尽管在20多年前被鉴定，但直到最近十年，这些细胞因子在健康和疾病中的功能才真正开始被认识，其中既有伤口愈合和对感染的反应中的稳态功能，也有现在认为的病理功能。在疾病背景下，IL-36的过度活化现在与许多炎性疾病相关，包括银屑病和炎性肠病，其在癌症中的作用也正在研究中。本文综述了IL-36生物学的现有知识，其在炎症性疾病中的作用，并重点介绍了IL-36在癌症中的新作用。
The IL-36 family of cytokines were first identified in 2000 based on their sequence homology to IL-1 cytokines. Over subsequent years, the ability of these cytokines to either agonise or antagonise an IL-1R homologue, now known as the IL-36 Receptor (IL-36R), was identified and these cytokines went through several cycles of renaming with the current nomenclature being proposed in 2010. Despite being identified over 20 years ago, it is only during the last decade that the function of these cytokines in health and disease has really begun to be appreciated, with both homeostatic functions in wound healing and response to infection, as well as pathological functions now ascribed. In the disease context, over activation of IL-36 has now been associated with many inflammatory diseases including Psoriasis and inflammatory bowel diseases, with roles in cancer also now being investigated. This review summarises the current knowledge of IL-36 biology, its role in inflammatory diseases and focuses on an emerging role for IL-36 in cancer.
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DOI：
10.4049/jimmunol.1301481
发表时间：
2014-06-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Foster AM;Baliwag J;Chen CS;Guzman AM;Stoll SW;Gudjonsson JE;Ward NL;Johnston A
通讯作者：
Johnston A
DOI：
10.1084/jem.20112258
发表时间：
2012-06-04
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Franzke CW;Cobzaru C;Triantafyllopoulou A;Löffek S;Horiuchi K;Threadgill DW;Kurz T;van Rooijen N;Bruckner-Tuderman L;Blobel CP
通讯作者：
Blobel CP
影响因子：
4.6
作者：
Boutet, M. -A.;Bart, G.;Blanchard, F.
通讯作者：
Blanchard, F.
影响因子：
4.4
作者：
Busfield, SJ;Comrack, CA;Pan, Y
通讯作者：
Pan, Y
影响因子：
--
作者：
Fonseca-Camarillo, Gabriela;Furuzawa-Carballeda, Janette;Yamamoto-Furusho, Jesus K.
通讯作者：
Yamamoto-Furusho, Jesus K.