Upregulation of Neuroinflammatory Protein Biomarkers in Acute Rhegmatogenous Retinal Detachments.
Upregulation of Neuroinflammatory Protein Biomarkers in Acute Rhegmatogenous Retinal Detachments.
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DOI：
10.3390/life13010118
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发表时间：
2022-12-31
期刊：
影响因子：
3.2
通讯作者：
Subramanian, Manju L.
中科院分区：
文献类型：
--
作者：
Prasad, Minali;Xu, Jia;Agranat, Joshua S.;Xia, Weiming;Daley, Sarah;Ness, Steven;Chen, Xuejing;Siegel, Nicole H.;Stein, Thor D.;Chung, Jaeyoon;Subramanian, Manju L.
关键词：
本研究的目的是描述孔源性视网膜脱离（RRD）与手术对照组相比的炎性细胞因子谱。玻璃体液收集自因RRD和非炎性玻璃体视网膜疾病接受玻璃体切除术的患者。采用定量免疫测定法测定36种细胞因子标志物的水平。对Shapiro-Wilk检验确定的正态分布细胞因子进行线性回归分析，其中以解脱持续时间作为预测因子，以对数转换的细胞因子水平作为结果。该分析根据年龄、性别和人种进行了调整。Kruskal-Wallis检验用于非正态分布的细胞因子。研究了27例RRD病例和13例对照病例。在所有RRD和对照组之间，成纤维细胞生长因子2（FGF 2）（p = 0.0029），诱导蛋白-10（IP-10）（p = 0.0021），单核细胞趋化蛋白-1（MCP-1）（p = 0.0040），白细胞介素（IL）-16（p = 0.018），IL-8（p = 0.0148），IL-6（p = 0.0071），嗜酸性粒细胞趋化因子（p = 0.0323），巨噬细胞炎性蛋白（MIP）-1 α在RRD病例中，MIP-1 β（p = 0.0032）和胸腺和活化调节细胞因子（TARC）（p = 0.0121）升高。在急性RRD（n = 16）和对照组之间，FGF 2（p = 0.0001）、IP 10（p = 0.0027）、MCP-1（p = 0.0015）、MIP-1β（p = 0.0004）、IL-8（p = 0.0146）和IL-6（p = 0.0031）升高。确定炎性细胞因子谱的改变可能有助于了解它们对RRD发展、临床病程和手术修复前后并发症的影响。
The purpose of this study is to characterize the inflammatory cytokine profile in rhegmatogenous retinal detachments (RRDs) compared to surgical controls. Vitreous humor was collected from patients undergoing vitrectomy for RRD and noninflammatory vitreoretinal diseases. A quantitative immunoassay was used to measure the levels of 36 cytokine markers. Linear regression analysis with the duration of detachment as the predictor and log-transformed cytokine levels as the outcome was conducted for normally distributed cytokines as determined by the Shapiro–Wilk test. The analysis was adjusted for age, sex, and race. The Kruskal–Wallis test was used for cytokines not normally distributed. Twenty-seven RRD cases and thirteen control cases were studied. Between all RRDs and controls, fibroblast growth factor 2 (FGF2) (p = 0.0029), inducible protein-10(IP-10) (p = 0.0021), monocyte chemoattractant protein-1 (MCP-1) (p = 0.0040), interleukin (IL)-16 (p = 0.018), IL-8 (p = 0.0148), IL-6 (p = 0.0071), eotaxin (p = 0.0323), macrophage inflammatory protein (MIP)-1 alpha (p = 0.0149), MIP-1 beta (p = 0.0032), and the thymus and activation regulated cytokine (TARC) (p = 0.0121) were elevated in RRD cases. Between acute RRDs (n = 16) and controls, FGF2 (p = 0.0001), IP10 (p = 0.0027), MCP-1 (p = 0.0015), MIP-1β (p = 0.0004), IL-8 (p = 0.0146), and IL-6 (p = 0.0031) were elevated. Determining alterations in inflammatory cytokine profiles may aid in understanding their impact on RRD development, clinical course, and complications before and after surgical repair.
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发表时间：
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期刊：
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影响因子：
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