Sleep duration and risk of atrial fibrillation (from the Physicians' Health Study).
Sleep duration and risk of atrial fibrillation (from the Physicians' Health Study).
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DOI：
10.1016/j.amjcard.2012.10.038
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发表时间：
2013-02-15
影响因子：
2.8
通讯作者：
Djousse, Luc
中科院分区：
文献类型：
--
作者：
Khawaja, Owais;Sarwar, Akmal;Albert, Christine M.;Gaziano, John Michael;Djousse, Luc
虽然睡眠质量和持续时间与心血管终点有关，但对睡眠持续时间与房颤（AF）事件之间的关系知之甚少。因此，我们前瞻性地研究了18，755名美国男性医生的睡眠时间与AF事件之间的关系。在2002年的年度随访问卷中确定了自我报告的睡眠时间。通过每年的随访问卷调查确定AF事件。考克斯回归用于估计AF的相对风险。基线时的平均年龄为67.7（+8.6）岁。在平均6.9（±2.1）年的随访期间，发生了1，468例AF。使用7小时睡眠作为参考组，从最低到最高类别的睡眠持续时间（p = 0.26），AF的多变量校正风险比（95% CI）分别为1.06（0.92-1.22）、1.0（参考）和1.13（1.00-1.27）。在二次分析中，没有证据表明肥胖会影响疗效（p相互作用=0.69）;然而，普遍的睡眠呼吸暂停改变了睡眠持续时间与AF的关系（p相互作用=0.01）：从睡眠时间的最高到最低类别，AF的多变量校正风险比（95%CI）为2.26（1.26-4.05）、1.0（ref）和1.34（0.73-2.46），对于患有普遍睡眠呼吸暂停的患者，分别为1.01（0.87-1.16）、1.0（ref）和1.12（0.99-1.27）。我们的数据显示，在美国男性医生中，睡眠时间长的房颤风险适度升高。此外，睡眠持续时间较短与普遍存在睡眠呼吸暂停的人发生AF的风险较高相关。
While sleep quality and duration have been related to cardiovascular endpoints, little is known about the association between sleep duration and incident atrial fibrillation (AF). Hence, we prospectively examined the association between sleep duration and incident AF in a cohort of 18,755 US male physicians. Self-reported sleep duration was ascertained during 2002 annual follow-up questionnaire. Incident AF was ascertained through yearly follow-up questionnaires. Cox regression was used to estimate relative risks of AF. The average age at baseline was 67.7 (+8.6) years. During a mean follow up of 6.9 (±2.1) years, 1,468 cases of AF occurred. Using 7 hours of sleep as the reference group, multivariable adjusted hazard ratios (95% CI) for AF were 1.06 (0.92–1.22), 1.0 (ref), and 1.13 (1.00–1.27) from the lowest to the highest category of sleep duration (p for trend 0.26), respectively. In a secondary analysis, there was no evidence of effect modification by adiposity (p interaction =0.69); however, prevalent sleep apnea modified the relation of sleep duration with AF (p interaction =0.01): from the highest to the lowest category of sleep duration, multivariable adjusted hazard ratios (95% CI) for AF were 2.26 (1.26–4.05), 1.0 (ref), and 1.34 (0.73–2.46) for those with prevalent sleep apnea and 1.01 (0.87–1.16), 1.0 (ref), and 1.12 (0.99–1.27) for those without sleep apnea, respectively. Our data showed a modestly elevated risk of AF with long sleep duration among US male physicians. Furthermore, shorter sleep duration was associated with a higher risk of AF in people with prevalent sleep apnea.
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影响因子：
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