[Guidelines on Treatment of Hypertension in the Elderly--2002 Revised Version].
[Guidelines on Treatment of Hypertension in the Elderly--2002 Revised Version].
复制标题
[老年高血压治疗指南--2002年修订版]。
DOI：
10.1291/hypres.26.1
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
H. Mikami
中科院分区：
文献类型：
--
作者：
Toshio Ogihara;K. Hiwada;S. Morimoto;H. Matsuoka;M. Matsumoto;S. Takishita;K. Shimamoto;K. Shimada;I. Abe;Yasuyoshi Ouchi;H. Tsukiyama;S. Katayama;Yutaka Imai;Hiromichi Suzuki;K. Kohara;K. Okaishi;H. Mikami
来自日本厚生劳动省老龄化与健康综合研究项目课题组：*1大阪大学研究生院、*2爱媛大学医学部、*3金泽医科大学、*4东京都大学医学部、*5琉球大学医学部、*6札幌医科大学、*7集知医学部、*8九州大学医学部、*9东京医学部研究生院、*10国际卫生与福利大学、*11齐玉医科大学。和*12日本东北大学药学研究生院。转载地址：日本大阪水田市山道冈2-2号大阪大学医学部老年医学系，医学博士，博士，邮编：565-0871。电子邮件：Ogihara@geriat.med.osaka-U.S.ac.jp已于2002年9月6日收到并接受。“新星”型。前者一般在中年发展为原发性高血压，随着年龄的增长舒张压降低而成为收缩期高血压，而后者则由于大动脉血管顺应性降低而在老年发展为高血压。此外，还有一些继发性高血压是由可识别的原因引起的，如肾血管性高血压。据报道，在老年人中，与舒张压相比，收缩压与心血管并发症--特别是中风、缺血性心脏病、心力衰竭、终末期肾病和各种原因死亡--的相关性更强。此外，研究还表明，脉压升高(收缩压和舒张压之间的差值)与此类并发症的风险增加相关。老年高血压的病理生理特征是外周血管总阻力增加，大中动脉顺应性降低，心输出量和循环血容量有减少的趋势，压力感受器功能的增龄性降低导致血压不稳定增加，血流量减少，脑、心、肾等重要靶器官的自我调节功能障碍。因此，引言
From the Research Group for “Long-Term Prognosis of Hypertension in the Elderly,” Comprehensive Research Projects on Aging and Health, the Ministry of Health, Labor and Welfare of Japan: *1Osaka University Graduate School of Medicine, *2Ehime University School of Medicine, *3Kanazawa Medical University, *4Dokkyo University School of Medicine, *5University of the Ryukyus School of Medicine, *6Sapporo Medical University, *7Jichi Medical School, *8Kyushu University, Graduate School of Medical Sciences, *9University of Tokyo Graduate School of Medicine, * 10International University of Health and Welfare, * 11Saitama Medical University, and * 12Tohoku University Graduate School of Pharmaceutical Science, Japan. Address for Reprints: Toshio Ogihara, M.D., Ph.D., Department of Geriatric Medicine, Osaka University Graduate School of Medicine, 2–2 Yamadaoka, Suita, Osaka 565–0871, Japan. E-mail: ogihara@geriat.med.osaka-u.ac.jp Received and Accepted September 6, 2002. novo” types. The former generally develops in middle age as essential hypertension, and becomes systolic hypertension as the diastolic blood pressure is reduced due to the aging process, while the latter develops in old age due to reduced vascular compliance in the large arteries. In addition, there are some cases with secondary hypertension due to identifiable causes such as renovascular hypertension. In the elderly, it has been reported that systolic blood pressure is more strongly related with cardiovascular complications—especially stroke, ischemic heart disease, heart failure, end-stage renal disease, and all-cause mortality—than is diastolic blood pressure (3). Furthermore, it has been demonstrated that increased pulse pressure (the difference between systolic blood pressure and diastolic blood pressure) is correlated with an increased risk of such complications (4). The pathophysiology of hypertension in the elderly is characterized by increased total peripheral vascular resistance, decreased compliance of large and middle arteries, a tendency toward decrease in cardiac output and circulating blood volume, increased lability of blood pressure due to age-related decrease in baroreceptor function, decreased blood flow, and dysfunction of autoregulation in important target-organs such as the brain, heart, and kidney. Therefore, Introduction
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影响因子：
120.7
作者：
Whelton, PK;Appel, LJ;Cutler, JA
通讯作者：
Cutler, JA
DOI：
10.1001/jama.1988.03720020027031
发表时间：
1988-01
期刊：
JAMA
影响因子：
--
作者：
T. Pickering;G. James;Charlene Boddie;G. Harshfield;S. Blank;J. Laragh
通讯作者：
T. Pickering;G. James;Charlene Boddie;G. Harshfield;S. Blank;J. Laragh
影响因子：
37.8
作者：
GREENBERG, B;QUINONES, MA;SHELTON, B
通讯作者：
SHELTON, B
影响因子：
158.5
作者：
Klag, MJ;Whelton, PK;Stamler, J
通讯作者：
Stamler, J
影响因子：
37.8
作者：
Franklin, SS;Khan, SA;Levy, D
通讯作者：
Levy, D