Development of dual-ended depth-of-interaction detectors using laser-induced crystals for small animal PET systems
Development of dual-ended depth-of-interaction detectors using laser-induced crystals for small animal PET systems
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使用激光诱导晶体开发用于小动物 PET 系统的双端交互深度探测器
DOI：
10.1088/1361-6560/ac18fc
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发表时间：
2021
影响因子：
3.5
通讯作者：
Yamaya Taiga
中科院分区：
文献类型：
--
作者：
Mohammadi Akram;Inadama Naoko;Nishikido Fumihiko;Yamaya Taiga
正电子发射断层扫描（PET）扫描仪的灵敏度和空间分辨率可以通过使用具有相互作用深度（DOI）编码的较厚闪烁晶体来提高。亚表面激光雕刻（SSLE）可用于分割闪烁探测器的晶体，以制造DOI探测器。我们之前将SSLE应用于3× 3× 20mm3和1.5× 1.5× 20mm3的晶体棒，并开发了两个DOI段分别为3mm和1.5mm的双端探测器。为了进一步提高DOI分辨率，我们的SSLE探测器设计可以与更小间距的晶体棒一起使用，使其成为具有亚毫米分辨率的小动物PET扫描仪的优秀探测器候选者。在本研究中，3个小的晶体棒1× 1× 20 mm3，2× 1× 20 mm3，2× 1× 40 mm3的激光雕刻分别为12，20和40段，应用SSLE在其高度方向。在三个原型检测器布置中表征了分段晶体棒。首先，1× 1× 20 mm 3晶体棒在8× 8晶体阵列中进行表征，该晶体阵列设计用于在常规小动物PET设计中沿沿着晶体高度进行DOI编码。其次，一个4× 8的2× 1× 20毫米3晶体棒的晶体阵列的特点是使用的DOI信息的晶体相互作用定位沿着小动物PET扫描仪的轴向轴。最后，在一个2× 1× 40 mm3的单晶棒上进行了第三部分的研究，以探讨在具有扩展轴向长度的系统中应用较长晶体的DOI估计的可行性。我们评估了这些探测器的片段识别能力和能量分辨率。使用Anger型计算获得探测器的3D位置图，并对每个探测器的晶体识别性能进行评估。对于具有12（1.67mm的片段间距）和20（1mm的片段间距）片段的晶体阵列，获得了清晰的片段分离。在511keV处，8× 8阵列12段和4× 8阵列20段中心区的平均能量分辨分别为8.8%±0.4%和9.6%±0.8%。发现对于具有40个片段的检测器，特别是对于晶体中间的片段，很难进行清晰的片段识别。能量和相互作用定位表征结果表明，这两个原型探测器与12和20段非常适合小动物PET扫描仪具有高空间分辨率。
Sensitivity and spatial resolution of positron emission tomography (PET) scanners can be improved by using thicker scintillation crystals with depth-of-interaction (DOI) encoding. Subsurface laser engraving (SSLE) can be used to segment crystals of a scintillation detector in order to fabricate a DOI detector. We previously applied SSLE to crystal bars of 3× 3× 20 mm 3 and 1.5× 1.5× 20 mm 3 and developed two dual-ended detectors with DOI segments of 3 mm and 1.5 mm, respectively. To further improve the DOI resolution, our SSLE detector design can be used with smaller pitch crystal bars, making them excellent detector candidates for small animal PET scanners with submillimetre resolution. In the present study, three small crystal bars of 1× 1× 20 mm 3, 2× 1× 20 mm 3, and 2× 1× 40 mm 3 were laser engraved to 12, 20 and 40 segments, respectively, by applying SSLE in their height directions. The segmented crystal bars were characterised in three prototype detector arrangements. First, the 1× 1× 20 mm 3 crystal bars were characterised in an 8× 8 crystal array designed for DOI encoding along crystal height in a conventional small animal PET design. Second, a 4× 8 crystal array of 2× 1× 20 mm 3 crystal bars was characterised for using the DOI information for crystal interaction positioning along the axial axis of a small animal PET scanner. Finally, the third part of the study was performed on a single 2× 1× 40 mm 3 crystal bar with 40 segments to investigate the feasibility of DOI estimation in longer crystals for application in a system with extended axial length. We evaluated the capability of segment identification and energy resolution of theses detectors. The 3D position maps of the detectors were obtained using the Anger-type calculation and the crystal identification performance was evaluated for each detector. Clear segment separation was obtained for the crystal arrays with 12 (segment pitch of 1.67 mm) and 20 (segment pitch of 1 mm) segments. Mean energy resolutions of 8.8%±0.4% and 9.6%±0.8% at 511 keV were obtained for the segments in the central regions of the 8× 8 array with 12 segments and the 4× 8 array with 20 segments, respectively. Clear segment identification was found to be difficult for the detector with 40 segments, especially for the segments at the middle of the crystal. Energy and interaction positioning characterisation results suggest that both prototype detectors with 12 and 20 segments are well suited for small animal PET scanners with high spatial resolution.
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一对原型系统中激光加工 Xtal 立方体探测器对 PET 成像的影响
影响因子：
1.8
作者：
E. Yoshida;Y. Hirano;H. Tashima;N. Inadama;F. Nishikido;T. Moriya;T. Omura;Mitsuo Watanabe;H. Murayama;T. Yamaya
通讯作者：
T. Yamaya
影响因子：
1.8
作者：
Tsuda, T;Murayama, H;Orita, N
通讯作者：
Orita, N
具有交互深度的 PET 探测器激光诱导层表面积的优化
DOI：
10.1016/j.nima.2021.165425
发表时间：
2021
影响因子：
1.4
作者：
A. Mohammadi;N. Inadama;F. Nishikido;T. Sakai;T. Yamaya
通讯作者：
T. Yamaya
使用通过次表面激光雕刻分割的晶棒开发具有 TOF 和 DOI 功能的双端探测器
DOI：
--
发表时间：
2019
期刊：
Nuclear Inst. and Methods in Physics Research
影响因子：
--
作者：
Akram Mohammadi;Sodai Takyu;Fumihiko Nishikido;Eiji Yoshida;Keiji Shimizu;Toshiaki Sakai;Taiga Yamaya
通讯作者：
Taiga Yamaya
影响因子：
3.5
作者：
T. Yamaya;T. Mitsuhashi;Takahiro Matsumoto;N. Inadama;F. Nishikido;E. Yoshida;H. Murayama;H. Kawai;M. Suga;Mitsuo Watanabe
通讯作者：
T. Yamaya;T. Mitsuhashi;Takahiro Matsumoto;N. Inadama;F. Nishikido;E. Yoshida;H. Murayama;H. Kawai;M. Suga;Mitsuo Watanabe