Concurrent and longitudinal associations of basal and diurnal cortisol with mental health symptoms in early adolescence.
Concurrent and longitudinal associations of basal and diurnal cortisol with mental health symptoms in early adolescence.
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DOI：
10.1002/dev.20336
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发表时间：
2008-11
影响因子：
2.2
通讯作者：
Essex, Marilyn J.
中科院分区：
文献类型：
--
作者：
Shirtcliff, Elizabeth A.;Essex, Marilyn J.
最近的生物社会理论假设生物风险和社会环境都影响心理健康问题的发展。在这个框架的指导下，我们研究了基础皮质醇及其昼夜节律是否与青春期早期的心理健康症状有关。由于横断面和纵向调查有时会揭示不同的皮质醇-心理健康关联，因此我们在儿童过渡到中学时同时和纵向地研究了这种关联，这一时期需要从单一教师到多个教师、教室和同学的社会环境发生重大变化。当青少年是五年级学生时，他们每天测量三次唾液皮质醇（醒着、下午和就寝时间）。心理健康是在青少年上五年级和七年级时进行测量的，就在他们升入中学之前和之后。为了处理内化和外化症状在这一发展阶段的大量共病，心理健康测量将整体症状严重程度与内化和外化症状的优势（即方向性）区分开来。采用三层次线性模型提取基础皮质醇及其日节律，将其与日常经历中皮质醇的日常和日内波动分开。结果是特定于症状严重程度的，表明皮质醇是青少年心理健康症状的非特异性危险因素。在5年级时，低基础皮质醇与并发症状严重程度相关。然而，从纵向上看，5年级时皮质醇水平高的青少年在7年级时出现心理健康症状的风险增加。五年级的平缓昼夜节律与五年级和七年级的症状严重程度水平相关。考虑到社会环境的变化，正如过渡到中学所定义的那样，有助于解决似乎不一致的证据，即低觉醒和高觉醒都与青春期早期的心理健康症状有关。
Recent biosocial theories postulate that both biological risk and the social context influence the development of mental health problems. Guided by this framework, we examined whether basal cortisol and its diurnal rhythm were associated with mental health symptoms in early adolescence. Because cross-sectional and longitudinal investigations sometimes reveal different cortisol-mental health associations, we examined the association both concurrently and longitudinally when children transition to middle school, a time which entails a major change in social context from single to multiple teachers, classrooms, and sets of classmates. Salivary cortisol was measured three times a day (waking, afternoon, and bedtime) across three days when adolescents were 5th graders. Mental health was measured when adolescents were in 5th and 7th grades, just before and after the transition to middle school. To deal with the substantial comorbidity of internalizing and externalizing symptoms at this developmental stage, mental health measures distinguished overall symptom severity from the preponderance of internalizing vs. externalizing symptoms (i.e., directionality). A three-level Hierarchical Linear Model was used to extract basal cortisol and its diurnal rhythm separate from the day-to-day and within-the-day fluctuations in cortisol in response to daily experiences. Results were specific to symptom severity, suggesting that cortisol is a nonspecific risk factor for mental health symptoms in young adolescents. At 5th grade, low basal cortisol was associated with concurrent symptom severity. However, longitudinally, it was adolescents with high cortisol at 5th grade who were at risk for increasing mental health symptoms by 7th grade. Flat diurnal rhythms in 5th grade were related to levels of symptom severity at both 5th and 7th grades. Considering the change in social context, as defined by the transition to middle school, helped resolve seemingly inconsistent evidence that both hypo- and hyper-arousal were associated with mental health symptoms in early adolescence.
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影响因子：
3.6
作者：
BOYCE, WT;ADAMS, S;GUNNAR, MR
通讯作者：
GUNNAR, MR
影响因子：
2.6
作者：
Bartels, M;de Geus, EJC;Boomsma, DI
通讯作者：
Boomsma, DI
DOI：
10.1196/annals.1308.032
发表时间：
2004-01-01
期刊：
ADOLESCENT BRAIN DEVELOPMENT: VULNERABILITIES AND OPPORTUNITIES
影响因子：
--
作者：
Carskadon, MA;Acebo, C;Jenni, OG
通讯作者：
Jenni, OG
影响因子：
3.7
作者：
Dockray, Samantha;Bhattacharyya, Mimi R.;Steptoe, Andrew
通讯作者：
Steptoe, Andrew
DOI：
10.1097/00004583-199609000-00010
发表时间：
1996-09-01
影响因子：
13.3
作者：
DeBellis, MD;Dahl, RE;Ryan, ND
通讯作者：
Ryan, ND