Effects of puerarin on cholinergic enzymes in the brain of ovariectomized guinea pigs
Effects of puerarin on cholinergic enzymes in the brain of ovariectomized guinea pigs
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葛根素对去势豚鼠脑内胆碱能酶的影响
DOI：
10.3109/00207454.2013.803103
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发表时间：
2013-05
影响因子：
2.2
通讯作者：
Xu Y.
中科院分区：
文献类型：
--
作者：
Shan Y.;Wang D.;Zhu C.;Xu Y.
雌激素对绝经后妇女的神经退行性疾病和认知功能具有有益的作用。葛根素是从野葛中分离出来的一种植物雌激素，对脑血管疾病有很好的治疗作用。本实验观察了葛根素对去卵巢豚鼠脑内神经胆碱能系统的影响。葛根素在所用剂量（15 mg/kg体重（bw）/天和30 mg/kg bw/天）下连续10天具有雌激素活性，表现为卵巢切除术引起的子宫重量减少减弱。在脑组织中，葛根素处理增加海马胆碱乙酰转移酶（ChAT）活性和表达，增加隔对角区ChAT免疫阳性信号。葛根素治疗可以抑制乙酰胆碱酯酶的表达和活性的增加，完整组的水平，虽然他们没有显着不同的卵巢切除动物。此外，葛根素还可降低海马β-淀粉样蛋白免疫阳性染色。总之，本研究表明葛根素可预防神经元胆碱能系统的功能障碍，并改善雌激素缺乏引起的β-淀粉样蛋白的增加。
Estrogen has beneficial effects on neurodegenerative disorders and cognitive function of postmenopausal women. Puerarin, isolated from Pueraria lobota, has been classified as a phytoestrogen, which can be highly effective against cerebrovascular diseases. In this study, the effects of puerarin on neural cholinergic system in the brain of ovariectomized guinea pigs were studied. The puerarin at the doses used (15 mg/kg body weight (bw)/day and 30 mg/kg bw/day) for 10 days had the estrogenic activity indicated by the attenuation of the reduction of uterine weight induced by ovariectomy. In brain, puerarin treatment increased choline acetyltransferase (ChAT) activity and expression in hippocampus, and increased ChAT immnuopositive signals in septal diagonal region. Puerarin treatment could suppress the increase of acetylcholinesterase expression and activity to the levels of the intact group, although they were not significantly different from those of the ovariectomized animals. Moreover, puerarin decreased the β-amyloid immunopositive staining in hippocampus. In brief, the present study suggests that puerarin prevents the dysfunction of the neuronal cholinergic system and ameliorates the increase of β-amyloid caused by estrogen deficiency.
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影响因子：
5.8
作者：
ELLMAN, GL;COURTNEY, KD;FEATHERSTONE, RM
通讯作者：
FEATHERSTONE, RM
影响因子：
4.9
作者：
W. Cherdshewasart;R. Panriansaen;P. Picha
通讯作者：
W. Cherdshewasart;R. Panriansaen;P. Picha
DOI：
10.3736/jcim20050521
发表时间：
2005-09
期刊：
Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
影响因子：
--
作者：
Shu-Fang Shi;Chao-Qin Yu
通讯作者：
Shu-Fang Shi;Chao-Qin Yu
影响因子：
5.3
作者：
Carroll, Jenna C.;Rosario, Emily R.;Pike, Christian J.
通讯作者：
Pike, Christian J.
影响因子：
4.8
作者：
Carroll, Jenna C.;Pike, Christian J.
通讯作者：
Pike, Christian J.