Synthetic nanoelectronic probes for biological cells and tissues.

Synthetic nanoelectronic probes for biological cells and tissues.
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DOI:
10.1146/annurev-anchem-062012-092623
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发表时间:
2013
期刊:
Annual review of analytical chemistry (Palo Alto, Calif.)
影响因子:
--
通讯作者:
Lieber CM
Lieber CM
中科院分区:
其他
文献类型:
--
作者:
Tian B;Lieber CM

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Research at the interface between nanoscience and biology has the potential to produce breakthroughs in fundamental science and lead to revolutionary technologies. In this review, we focus on nanoelectronic/biological interfaces. First, we discuss nanoscale field effect transistors (nanoFETs) as probes to study cellular systems, including the realization of nanoFET comparable in size to biological nanostructures involved in communication using synthesized nanowires. Second, we overview current progress in multiplexed extracellular sensing using planar nanoFET arrays. Third, we describe the design and implementation of three distinct nanoFETs used to realize the first intracellular electrical recording from single cells. Fourth, we present recent progress in merging electronic and biological systems at the 3D tissue level by using macroporous nanoelectronic scaffolds. Finally, we discuss future development in this research area, the unique challenges and opportunities, and the tremendous impact these nanoFET based technologies might have in advancing biology and medical sciences.
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