Microstructural tissue damage in normal appearing brain tissue accumulates with Framingham Stroke Risk Profile Score: magnetization transfer imaging results of the Austrian Stroke Prevention Study.
Microstructural tissue damage in normal appearing brain tissue accumulates with Framingham Stroke Risk Profile Score: magnetization transfer imaging results of the Austrian Stroke Prevention Study.
复制标题
DOI：
10.1016/j.clineuro.2012.12.016
复制
发表时间：
2013-08
影响因子：
1.9
通讯作者：
Schmidt R
中科院分区：
文献类型：
--
作者：
Homayoon N;Ropele S;Hofer E;Schwingenschuh P;Seiler S;Schmidt R
磁化传递成像检测脑微结构组织改变。我们检查了临床正常老年受试者的病理和正常脑组织中弗雷明汉中风风险概况（FSRP）评分与磁化传递成像（MTI）测量值之间的关联，以确定中风风险是否会导致脑组织破坏超出常规MRI扫描中可见的范围。该研究队列来自奥地利卒中预防研究（ASPS）。共有316名受试者接受了MTI，并进行了足以计算FSRP评分的完整风险因素评估。有205名女性和111名男性，平均年龄为70.2岁，范围为54至82岁。受试者被分为四类中风风险概率，男性为3%至88%，女性为1%至84%。较高的FSRP评分与MTR峰位置偏移显著且独立相关，表明脑组织（BT）和正常外观脑组织（NABT）中的整体显微结构改变。白色高信号（WMH）的平均MTR与卒中风险增加呈负相关。年龄解释了MTR峰值位置的大部分变异，FSRP评分的所有其他风险因素均具有显著贡献，但仅解释了该MRI测量的额外2%的变异。中风风险的增加导致标准MRI无法看到的微结构大脑变化。这些异常的有效性，潜在的致病机制和临床意义需要进一步确定。
Magnetization transfer imaging detects cerebral microstructural tissue alterations. We examined the association between the Framingham Stroke Risk Profile (FSRP) score and magnetization transfer imaging (MTI) measures in pathological and normal appearing brain tissue in clinically normal elderly subjects to determine if stroke risk leads to brain tissue destruction beyond what is visible in conventional MRI scans. The study cohort is from the Austrian Stroke Prevention Study (ASPS). A total of 316 subjects underwent MTI and had a complete risk factor assessment sufficient to calculate the FSRP score. There were 205 women and 111 men with a mean age of 70.2 years ranging from 54 to 82 years. Subjects were grouped into four categories of stroke risk probability ranging from 3% to 88% for men and 1% to 84% for women. A higher FSRP score was significantly and independently associated with a MTR peak position shift indicating global microstructural alterations in brain tissue (BT) and in normal appearing brain tissue (NABT). The mean MTR in white matter hyperintensities (WMH) correlated inversely with increasing stroke risk. Age explained most of the variance in MTR peak position, all other risk factors of the FSRP score contributed significantly but explained an additional 2% of the variance of this MRI measure, only. Increasing risk for stroke leads to microstructural brain changes invisible by standard MRI. The validity, the underlying pathogenic mechanisms and the clinical importance of these abnormalities needs to be further determined.
登录
查看更多内容
影响因子：
--
作者：
KERTESZ, A;BLACK, SE;NICHOLSON, L
通讯作者：
NICHOLSON, L
影响因子：
9.9
作者：
FISHER, CM
通讯作者：
FISHER, CM
影响因子：
8.3
作者：
Jeerakathil, T;Wolf, PA;DeCarli, C
通讯作者：
DeCarli, C
影响因子：
14.5
作者：
Fazekas, F;Ropele, S;Schmidt, R
通讯作者：
Schmidt, R
影响因子：
4.4
作者：
Schmidt, R;Fazekas, F;Esterbauer, H
通讯作者：
Esterbauer, H