Homologs of bacterial heat-labile enterotoxin subunit A contribute to development, stress response, and virulence in filamentous entomopathogenic fungus Beauveria bassiana.
Homologs of bacterial heat-labile enterotoxin subunit A contribute to development, stress response, and virulence in filamentous entomopathogenic fungus Beauveria bassiana.
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DOI：
10.3389/fimmu.2023.1264560
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发表时间：
2023
影响因子：
7.3
通讯作者：
Ying, Sheng-Hua
中科院分区：
文献类型：
--
作者：
Ding, Jin-Li;Wei, Kang;Feng, Ming-Guang;Ying, Sheng-Hua
Enterotoxigenic bacteria commonly excrete heat-labile enterotoxins (LT) as virulence factors that consist of one subunit A (LTA) and five B subunits (LTB). In fungi, there are a large number of genes encoding the homologs of LTA, but their biological roles remain largely unknown. In this study, we identified 14 enterotoxin_A domain proteins in filamentous fungus B. bassiana in which five proteins were functionally characterized. Five proteins displayed diverse sub-cellular localizations but perform convergent functions in stress response, development, and virulence. The loss of five LTA genes resulted in significant reduction in conidial production, blastospore formation, and the increased sensitivity to oxidative and cell wall –perturbing stresses. The virulence of five disruptants was notably weakened as indicated by topical and intrahemocoel injection assays. Notably, the loss of these five proteins led to the significant changes in the carbohydrate profiles of cellular surface, which induced the enhanced host immune reactions of encapsulation and melanization. Thus, LTA proteins contribute to the fungus–host interaction via maintaining the carbohydrate profiles of cellular surface. This study expands our understanding of the enterotoxin_A domain proteins in fungal physiology and deepens mechanisms involved in the lifestyle of fungal insect pathogens.
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影响因子：
5.1
作者：
Ding, Jin-Li;Lin, Hai-Yan;Ying, Sheng-Hua
通讯作者：
Ying, Sheng-Hua
影响因子：
5.8
作者：
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通讯作者：
Ying, Sheng-Hua
影响因子：
64.8
作者：
STEINER, H;HULTMARK, D;BOMAN, HG
通讯作者：
BOMAN, HG
影响因子：
6.4
作者：
通讯作者：
--
影响因子：
2.9
作者：
Maistrou, Sevasti;Natsopoulou, Myrsini E.;Meyling, Nicolai, V
通讯作者：
Meyling, Nicolai, V