The many faces of recruitment in a randomized controlled trial.
The many faces of recruitment in a randomized controlled trial.
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随机对照试验中招募的多面性。
DOI：
10.1016/j.cct.2021.106285
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发表时间：
2021-03
影响因子：
2.2
通讯作者：
Dunsiger, Shira I.
中科院分区：
文献类型：
--
作者：
Pinto, Bernardine M.;Dunsiger, Shira I.
研究招募的深思熟虑的方法是设计和实施随机对照试验的关键一步。招聘的延迟和挑战可能代价高昂，并可能导致样本量小于拟议的样本量，从而产生下游影响，如研究力度不足。目前的研究评估了招募方法(例如，定向邮寄、小册子/传单、社交媒体)及其与资格、随机化、参与者特征和乳腺癌幸存者体力活动采用和维持的随机对照试验结束时的关系。对874名妇女的筛查数据进行了招募方法、研究资格、随机性和治疗结束前保留情况的分析。通过招募的方法计算每个随机参与者的成本。比较了不同招募方法以及随机和保留参与者之间的基线参与者特征。根据招募方法的不同，通过随机筛选资格的参与者的应收率在统计学上有显著差异(p<；0.05)。通过定向邮寄获得的随机率最高(88.2%)，通过宣传册/传单获得的随机率最低(0.4%)。在随机样本中，不同招聘方法之间的人口统计特征没有差异，但在定向邮寄类别(登记处与组织招聘)中存在差异。不同的招聘方法(p<；.001)的成本有统计学上的显著差异，其中最低的(不可忽略的)成本是定向邮寄。目前的乳腺癌幸存者随机对照试验成功招募和保留了参与者，强调需要结合招募方法来实现应计目标。招募方法在成本和吸引最终将被随机分配的个人的能力方面存在很大差异。
Thoughtful approaches to study recruitment are a critical step in designing and implementing randomized controlled trials. Delays and challenges in recruitment can be costly and can result in smaller than proposed sample sizes which have downstream effects, such as underpowered studies. The current study evaluated recruitment methods (e.g., targeted mailings, brochures/flyers, social media) and their relationship to eligibility, randomization, participant characteristics and retention at end of a randomized controlled trial of physical activity adoption and maintenance among breast cancer survivors. Screening data from 874 women was analyzed for recruitment method, study eligibility, randomization and retention through end of treatment. Costs per randomized participant were calculated by recruitment method. Baseline participant characteristics were compared across recruitment methods and between randomized and retained participants. Rates of participant accrual from eligibility screening through randomization differed statistically significantly depending on recruitment method (p <.05). The highest randomization rates were obtained via targeted mailings (88.2%) and lowest via brochure/flyer (0.4%). Among the randomized sample, there were no differences in demographic characteristics between recruitment methods, however, there were differences within the targeted mailings category (registries vs. organizational recruitment). There were statistically significant differences in costs between recruitment methods (p<.001) with lowest (non-negligible) cost being targeted mailings. The current RCT of breast cancer survivors successfully recruited and retained participants, highlighting the need to combine recruitment methods to achieve accrual goals. Recruitment methods differed substantially in their cost and their ability to attract individuals who would ultimately be randomized.
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