Bioactive skin-mimicking hydrogel band-aids for diabetic wound healing and infectious skin incision treatment.
Bioactive skin-mimicking hydrogel band-aids for diabetic wound healing and infectious skin incision treatment.
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生物活性仿皮肤水凝胶创可贴，用于糖尿病伤口愈合和感染性皮肤切口治疗。
DOI：
10.1016/j.bioactmat.2021.04.007
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发表时间：
2021-11
影响因子：
18.9
通讯作者：
Cheng Y
中科院分区：
文献类型：
--
作者：
Yang Y;Zhao X;Yu J;Chen X;Wang R;Zhang M;Zhang Q;Zhang Y;Wang S;Cheng Y
由于愈合过程中炎症反应上调、氧化应激和持续感染，糖尿病慢性伤口的治疗仍然是全球性的挑战。开发具有理想的生物相容性、足够的机械强度、相当大的水下粘附性、足够的抗炎、抗氧化和抗菌性能的伤口敷料材料是临床应用的需求。在这项研究中，我们开发了一种生物活性的仿皮肤水凝胶创可贴，通过结合单宁酸（TA）和咪唑烷基脲增强聚氨酯（PMI）（TAP水凝胶），并探讨其在各种医疗应用中的潜力，包括止血，正常皮肤切口，全层皮肤伤口，和细菌感染皮肤切口糖尿病小鼠。将TA负载到PMI水凝胶网络中，通过多种非共价相互作用增强TAP水凝胶的力学性能（断裂强度：0.28-0.64 MPa;断裂伸长率：650-930%），其可以抵抗局部应力并在应用过程中保持伤口敷料的结构完整性。此外，TAP水凝胶还具有良好的防潮止血和器官止血作用，以及显著的抗炎、抗菌和抗氧化特性，可有效促进糖尿病小鼠皮肤切口和缺损的修复。为了进一步模拟实际情况，探索其在临床应用中的潜力，我们还验证了TAP水凝胶对S。金黄色葡萄球菌感染的皮肤切口模型。通过单宁酸与聚氨酯的结合，研制出具有生物活性的仿皮肤水凝胶。在糖尿病小鼠上研究了生物活性仿皮肤水凝胶对伤口愈合和感染皮肤切口的闭合作用。
The treatment of diabetic chronic wounds remains a global challenge due to the up-regulated inflammation response, oxidant stress, and persistent infection during healing process. Developing wound dressing materials with ideal biocompatibility, adequate mechanical strength, considerable under-water adhesion, sufficient anti-inflammation, antioxidant, and antibacterial properties is on-demand for clinical applications. In this study, we developed a bioactive skin-mimicking hydrogel band-aid through the combination of tannic acid (TA) and imidazolidinyl urea reinforced polyurethane (PMI) (TAP hydrogel) and explored its potentials in various medical applications, including hemostasis, normal skin incision, full-thickness skin wounds, and bacterial-infection skin incision on diabetic mice. TA was loaded into PMI hydrogel network to enhance the mechanical properties of TAP hydrogels through multiple non-covalent interactions (break strength: 0.28–0.64 MPa; elongation at break: 650–930%), which could resist the local stress and maintain the structural integrity of wound dressings during applications. Moreover, owing to the promising moisture-resistant adhesiveness and organ hemostasis, outstanding anti-inflammation, antibacterial, and antioxidant properties, TAP hydrogels could efficiently promote the recovery of skin incision and defects on diabetic mice. To further simulate the practical situation and explore the potential in clinical application, we also verified the treatment efficiency of TAP hydrogel in S. aureus-infected skin incision model on diabetic mice. Bioactive skin-mimicking hydrogels were developed through the combination of tannic acid and polyurethane. The wound healing and infected skin incision closure by the bioactive skin-mimicking hydrogels were studied on diabetic mice.
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通讯作者：
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