Dietary n-3 Polyunsaturated Fatty Acids in Late Pregnancy and Postpartum Depressive Symptom among Japanese Women.
Dietary n-3 Polyunsaturated Fatty Acids in Late Pregnancy and Postpartum Depressive Symptom among Japanese Women.
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DOI：
10.3389/fpsyt.2017.00241
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发表时间：
2017
影响因子：
4.7
通讯作者：
Fujiwara T
中科院分区：
文献类型：
--
作者：
Kobayashi M;Ogawa K;Morisaki N;Tani Y;Horikawa R;Fujiwara T
n-3多不饱和脂肪酸（n-3 PUFA）在产后抑郁症的预防或治疗方式中的用途，特别是长链类型如二十碳五烯酸（EPA）和二十二碳六烯酸（DHA），是相当令人感兴趣的。据报道，日本孕妇的n-3 PUFA摄入量很高。因此，对这一组的分析可以为产后抑郁症和饮食n-3 PUFA消耗之间的关系提供重要的见解。为了进一步研究产后抑郁症风险与n-3 PUFA摄入量之间的关系，我们在日本进行了一项前瞻性的基于医院的出生队列研究。我们的前瞻性出生队列研究在日本东京郊区的国家儿童健康与发展中心（NCCHD）进行。通过半定量食物调查问卷评估妊娠晚期的饮食n-3 PUFA摄入量，并根据n-3 PUFA摄入量的五分位分布对参与者进行分类。爱丁堡产后抑郁量表的日语翻译被用来筛选妇女产后抑郁症在分娩后1个月（967名妇女）和分娩后6个月（710名妇女）。我们进行了逻辑回归分析，以检查产后抑郁症的风险和n-3 PUFA消费调整后的混杂因素之间的关系。未观察到妊娠晚期EPA、DHA和n-3 PUFA摄入量与产后1个月和6个月的产后抑郁症之间存在显著相关性。这项前瞻性研究表明，在怀孕后期摄入EPA，DHA和n-3 PUFA与产后抑郁症的风险无关。
The use of n-3 polyunsaturated fatty acids (n-3PUFA) in preventive or therapeutic modalities for postpartum depression, especially long-chain types such as eicosapentaenoic acid (EPA) and a docosahexaenoic acid (DHA), is of considerable interest. High n-3PUFA consumption has been reported among pregnant Japanese women. Therefore, analysis of this group could provide important insights into the relationship between postpartum depression and dietary n-3PUFA consumption. To further examine the relationship between the risk of postpartum depression and n-3PUFA consumption, we conducted a prospective hospital-based birth cohort study in Japan. Our prospective birth cohort study was performed at the National Center for Child Health and Development (NCCHD) in suburban Tokyo, Japan. Dietary n-3PUFA intake during late pregnancy was assessed by a semi-quantitative food questionnaire and participants were categorized by quintile distributions of n-3PUFA intake. A Japanese translation of the Edinburgh Postnatal Depression Scale was used to screen women for postpartum depression at 1 month after delivery (967 women) and at 6 months after delivery (710 women). We performed logistic regression analysis to examine the relationship between the risk of postpartum depression and n-3PUFA consumption after adjusting for confounding factors. Significant associations between EPA, DHA, and n-3PUFA intakes in late pregnancy and postpartum depression at both 1 and 6 months after delivery were not observed. This prospective study indicated that EPA, DHA, and n-3PUFA intake during late pregnancy was not associated with the risk of postpartum depression.
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