Using Plasma Autoantibodies of Central Nervous System Proteins to Distinguish Veterans with Gulf War Illness from Healthy and Symptomatic Controls.
Using Plasma Autoantibodies of Central Nervous System Proteins to Distinguish Veterans with Gulf War Illness from Healthy and Symptomatic Controls.
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DOI：
10.3390/brainsci10090610
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发表时间：
2020-09-05
期刊：
影响因子：
3.3
通讯作者：
Sullivan K
中科院分区：
文献类型：
--
作者：
Abou-Donia MB;Lapadula ES;Krengel MH;Quinn E;LeClair J;Massaro J;Conboy LA;Kokkotou E;Abreu M;Klimas NG;Nguyen DD;Sullivan K
在过去的30年里，一直缺乏客观的工具来诊断海湾战争疾病（GWI），这种疾病主要以1991年海湾战争（GW）退伍军人出现的中枢神经系统（CNS）症状为特征。在最近的一项初步研究中，我们报道了GWI退伍军人血液中存在针对中枢神经系统蛋白的自身抗体，这表明该疾病可能是一种客观的生物标志物。现在，我们报告了一项更大规模的确证性研究的结果，该研究将171名患有GWI的退伍军人与60名健康的GW退伍军人对照和85名有症状的平民对照（n = 50名肌痛性脑脊髓炎/慢性疲劳综合征（ME/CFS）和35名肠易激综合征（IBS））进行了比较。具体来说，我们比较了四组（GWI， GW对照组，ME/CFS， IBS）的血浆CNS自身抗体标记物的诊断特征。对于患有GWI的退伍军人，结果显示，针对神经元“微管蛋白、神经丝蛋白（NFP）、微管相关蛋白-2 （MAP-2）、微管相关蛋白-Tau （Tau）、α突触核蛋白（α-syn）、钙调蛋白激酶II （CaMKII）”和胶质蛋白“胶质纤维酸性蛋白（GFAP）、髓鞘相关糖蛋白（MAG）、髓鞘碱性蛋白（MBP）”的10种自身抗体中，有9种的水平有统计学意义上的升高。与健康GW对照者以及患有ME/CFS和IBS的平民相比。接下来，我们将每组的中枢神经系统自身抗体的所有平均值汇总成一个新的指数得分，称为神经变性指数（NDI）。计算了每个测试组的NDI值，结果显示GWI退伍军人的NDI值在统计学上显著高于所有三个对照组。本研究证实了血浆自身抗体对CNS蛋白的效用，以区分退伍军人GWI和其他健康和有症状的对照组。
For the past 30 years, there has been a lack of objective tools for diagnosing Gulf War Illness (GWI), which is largely characterized by central nervous system (CNS) symptoms emerging from 1991 Gulf War (GW) veterans. In a recent preliminary study, we reported the presence of autoantibodies against CNS proteins in the blood of veterans with GWI, suggesting a potential objective biomarker for the disorder. Now, we report the results of a larger, confirmatory study of these objective biomarkers in 171 veterans with GWI compared to 60 healthy GW veteran controls and 85 symptomatic civilian controls (n = 50 myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and n = 35 irritable bowel syndrome (IBS)). Specifically, we compared plasma markers of CNS autoantibodies for diagnostic characteristics of the four groups (GWI, GW controls, ME/CFS, IBS). For veterans with GWI, the results showed statistically increased levels of nine of the ten autoantibodies against neuronal “tubulin, neurofilament protein (NFP), Microtubule Associated Protein-2 (MAP-2), Microtubule Associated Protein-Tau (Tau), alpha synuclein (α-syn), calcium calmodulin kinase II (CaMKII)” and glial proteins “Glial Fibrillary Acidic Protein (GFAP), Myelin Associated Glycoprotein (MAG), Myelin Basic Protein (MBP), S100B” compared to healthy GW controls as well as civilians with ME/CFS and IBS. Next, we summed all of the means of the CNS autoantibodies for each group into a new index score called the Neurodegeneration Index (NDI). The NDI was calculated for each tested group and showed veterans with GWI had statistically significantly higher NDI values than all three control groups. The present study confirmed the utility of the use of plasma autoantibodies for CNS proteins to distinguish among veterans with GWI and other healthy and symptomatic control groups.
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