Moderate Adolescent Ethanol Vapor Exposure and Acute Stress in Adulthood: Sex-Dependent Effects on Social Behavior and Ethanol Intake in Sprague-Dawley Rats.
Moderate Adolescent Ethanol Vapor Exposure and Acute Stress in Adulthood: Sex-Dependent Effects on Social Behavior and Ethanol Intake in Sprague-Dawley Rats.
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DOI：
10.3390/brainsci10110829
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发表时间：
2020-11-07
期刊：
影响因子：
3.3
通讯作者：
Diaz MR
中科院分区：
文献类型：
--
作者：
Gamble ME;Diaz MR
青少年饮酒会导致许多后果，包括应激反应改变，以及以后患焦虑症和酒精使用障碍的风险增加。许多研究都研究了大量酒精暴露在青春期的后果，但对较低水平的醉酒的了解要少得多。目前的研究考察了适度的青少年酒精暴露作为成年后增加应激反应的可能因素，通过一般和社交焦虑样行为以及自愿酒精摄入量来衡量。雄性和雌性SD大鼠在青春期早期接受了青春期慢性间歇性乙醇(ACIE)蒸气暴露，达到了中等的血液乙醇浓度。然后，动物在成年后经历了两天的强迫游泳压力。我们发现，接触乙醇的男性比空气中的男性消耗更多的乙醇，而且男性中存在有趣的压力和酒精暴露的交互作用。对女性自愿饮酒没有显著影响。然而，社交互动测试显示，在两天的压力暴露后，接触酒精的女性玩耍打架行为增加，女性的社交偏好降低。总体而言，这项工作为适中Acie和成年后对急性应激的易感性提供了性别特异性的长期影响的证据。
Adolescent alcohol use can lead to numerous consequences, including altered stress reactivity and higher risk for later anxiety and alcohol use disorders. Many studies have examined the consequences of heavy ethanol exposure in adolescence, but far less is understood about lower levels of intoxication. The present study examined moderate adolescent ethanol exposure as a possible factor in increasing stress reactivity in adulthood, measured through general and social anxiety-like behaviors, as well voluntary ethanol intake. Male and female Sprague–Dawley rats underwent an adolescent chronic intermittent ethanol (aCIE) vapor exposure during early adolescence, reaching moderate blood ethanol concentrations. Animals then underwent two days of forced swim stress in adulthood. We found that ethanol-exposed males consumed more ethanol than their air counterparts and an interesting stress and ethanol exposure interaction in males. There were no significant effects on voluntary drinking in females. However, the social interaction test revealed increased play-fighting behavior in ethanol-exposed females and reduced social preference in females after two days of stress exposure. Overall, this work provides evidence for sex-specific, long-term effects of moderate aCIE and susceptibility to acute stress in adulthood.
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影响因子：
4.7
作者：
del Piero, Larissa B.;Saxbe, Darby E.;MargolinDepartment, Gayla
通讯作者：
MargolinDepartment, Gayla
影响因子：
3.6
作者：
Fuellgrabe, Marc W.;Vengeliene, Valentina;Spanagel, Rainer
通讯作者：
Spanagel, Rainer
影响因子：
3.3
作者：
Allen CD;Grigoleit JS;Hong J;Bae S;Vaughan J;Lee S
通讯作者：
Lee S
青春期乙醇暴露会减少成人前脑 ChAT+IR 神经元：与行为病理学的相关性。
影响因子：
3.3
作者：
Ehlers, C. L.;Criado, J. R.;Wills, D. N.;Liu, W.;Crews, F. T.
通讯作者：
Crews, F. T.
影响因子：
4.2
作者：
Duncan, SC;Alpert, A;Hops, H
通讯作者：
Hops, H