Predictors of arterial stiffness in adolescents and adults with type 1 diabetes: a cross-sectional study.
Predictors of arterial stiffness in adolescents and adults with type 1 diabetes: a cross-sectional study.
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DOI：
10.1136/bmjdrc-2021-002491
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发表时间：
2022-01
影响因子：
4.1
通讯作者：
Barrett EJ
中科院分区：
文献类型：
--
作者：
Love KM;Horton WB;Patrie JT;Jahn LA;Hartline LM;Barrett EJ
与年龄匹配的健康对照组相比，1型糖尿病患者的动脉僵硬程度更高。我们的目标是确定哪些血流动力学和人口统计学因素可以预测这一人群中的动脉僵硬。对41例无微血管并发症的青年和青少年1型糖尿病患者进行颈动脉-股动脉脉搏波速度(CfPWV)检测。用两个普通的最小二乘回归分析来确定cfPWV(LOGE)与(1)年龄、糖尿病病程、性别和Hb A1c和(2)增强指数(AIX)、平均动脉压、血流介导的扩张(FMD)和心率之间的多变量关系。我们还检查了不同性别在大血管结局指标上的差异。年龄、性别和FMD为1型糖尿病患者的cfPWV提供了独特的预测信息。尽管有相似的心血管危险因素，但男性的cfPWV高于女性，但在其他大血管结果(包括FMD和AIX)方面没有观察到差异。只有年龄、性别和FMD与青少年和成人无并发症的1型糖尿病患者的动脉僵硬有关。与男性相比，女性的动脉僵硬程度较低，并具有相似的一氧化氮依赖的内皮功能。有必要进行更大规模的前瞻性研究，以确定1型糖尿病患者动脉功能障碍的时间顺序和性别差异。
Individuals with type 1 diabetes have increased arterial stiffness compared with age-matched healthy controls. Our aim was to determine which hemodynamic and demographic factors predict arterial stiffness in this population. Carotid-femoral pulse wave velocity (cfPWV) was examined in 41 young adults and adolescents with type 1 diabetes without microvascular complications. Two ordinary least squares regression analyses were performed to determine multivariate relationships between cfPWV (loge) and (1) age, duration of diabetes, sex, and hemoglobin A1c and (2) augmentation index (AIx), mean arterial pressure, flow-mediated dilation (FMD), and heart rate. We also examined differences in macrovascular outcome measures between sexes. Age, sex, and FMD provided unique predictive information about cfPWV in these participants with type 1 diabetes. Despite having similar cardiovascular risk factors, men had higher cfPWV compared with women but no differences were observed in other macrovascular outcomes (including FMD and AIx). Only age, sex, and FMD were uniquely associated with arterial stiffness in adolescents and adults with uncomplicated type 1 diabetes. Women had less arterial stiffness and similar nitric oxide-dependent endothelial function compared with men. Larger, prospective investigation is warranted to determine the temporal order of and sex differences in arterial dysfunction in type 1 diabetes.
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影响因子：
5.3
作者：
Koivistoinen, Teemu;Virtanen, Marko;Kahonen, Mika
通讯作者：
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影响因子：
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8.3
作者：
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通讯作者：
Safar, ME