Hippocampal volume reduction in congenital central hypoventilation syndrome.
Hippocampal volume reduction in congenital central hypoventilation syndrome.
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DOI：
10.1371/journal.pone.0006436
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发表时间：
2009-07-30
期刊：
影响因子：
3.7
通讯作者：
Harper RM
中科院分区：
文献类型：
--
作者：
Macey PM;Richard CA;Kumar R;Woo MA;Ogren JA;Avedissian C;Thompson PM;Harper RM
先天性中枢性低通气综合征（CCHS）是一种遗传性疾病，其特征是睡眠期间呼吸动力减弱和CO2敏感性受损，在磁共振成像（MRI）扫描中显示大脑结构和功能变化，特定海马区域的反应受损，表明局部损伤。我们评估了海马表面形态的总体积和区域变化，以确定综合征中受影响的区域。我们研究了18名CCHS儿童（平均年龄±标准年龄：15.1±2.2岁; 8名女性）和32名健康对照儿童（年龄15.2±2.4岁; 14名女性），并在1 mm 3分辨率T1加权扫描上追踪了CCHS儿童的大脑皮层，使用3.0 Tesla MRI扫描仪收集。区域海马体积的变化，调整颅骨体积，进行了比较组之间的基础上的表面距离的结构中线的t检验，校正多重比较。CCHS患者左侧出现显著组织损失，右侧有损失趋势;然而，左侧受影响的大多数区域也显示出等同的右侧体积减少。区域体积减少出现在左侧吻侧海马、中部和中尾侧区域的双侧区域以及邻近海马伞的背尾侧区域。容量损失可能是由于睡眠呼吸障碍期间通气不足后的缺氧暴露，或综合征中基因突变的发育或血管后果。变化的部位与呼吸和自主神经挑战的异常功能反应区域重叠。受影响的海马区与记忆、情绪和间接的自主调节相关;这些行为和生理功能的损伤出现在CCHS中。
Children with congenital central hypoventilation syndrome (CCHS), a genetic disorder characterized by diminished drive to breathe during sleep and impaired CO2 sensitivity, show brain structural and functional changes on magnetic resonance imaging (MRI) scans, with impaired responses in specific hippocampal regions, suggesting localized injury. We assessed total volume and regional variation in hippocampal surface morphology to identify areas affected in the syndrome. We studied 18 CCHS (mean age±std: 15.1±2.2 years; 8 female) and 32 healthy control (age 15.2±2.4 years; 14 female) children, and traced hippocampi on 1 mm3 resolution T1-weighted scans, collected with a 3.0 Tesla MRI scanner. Regional hippocampal volume variations, adjusted for cranial volume, were compared between groups based on t-tests of surface distances to the structure midline, with correction for multiple comparisons. Significant tissue losses emerged in CCHS patients on the left side, with a trend for loss on the right; however, most areas affected on the left also showed equivalent right-sided volume reductions. Reduced regional volumes appeared in the left rostral hippocampus, bilateral areas in mid and mid-to-caudal regions, and a dorsal-caudal region, adjacent to the fimbria. The volume losses may result from hypoxic exposure following hypoventilation during sleep-disordered breathing, or from developmental or vascular consequences of genetic mutations in the syndrome. The sites of change overlap regions of abnormal functional responses to respiratory and autonomic challenges. Affected hippocampal areas have roles associated with memory, mood, and indirectly, autonomic regulation; impairments in these behavioral and physiological functions appear in CCHS.
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影响因子：
3.3
作者：
Macey, PM;Woo, MA;Harper, RM
通讯作者：
Harper, RM
影响因子：
2.3
作者：
Henderson, LA;Macey, KE;Harper, RM
通讯作者：
Harper, RM
影响因子：
3.5
作者：
Huefner, Katharina;Hamilton, Derek A.;Brandt, Thomas
通讯作者：
Brandt, Thomas
影响因子：
5.7
作者：
Morra JH;Tu Z;Apostolova LG;Green AE;Avedissian C;Madsen SK;Parikshak N;Toga AW;Jack CR Jr;Schuff N;Weiner MW;Thompson PM;Alzheimer's Disease Neuroimaging Initiative
通讯作者：
Alzheimer's Disease Neuroimaging Initiative
影响因子：
2.5
作者：
ALLEN, GV;HOPKINS, DA
通讯作者：
HOPKINS, DA