A cognitive process occurring during sleep is revealed by rapid eye movements.
A cognitive process occurring during sleep is revealed by rapid eye movements.
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DOI：
10.1126/science.abp8852
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发表时间：
2022-08-26
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--
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--
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自从快速眼动睡眠(REM)被发现以来，表征这一睡眠阶段的眼球运动的本质一直难以捉摸。它们揭示了梦的虚拟环境中的视线转移，还是仅仅反映了随机的脑干活动？我们利用了小鼠丘脑的头部方向(HD)系统，丘脑是一个神经元群体，在清醒的小鼠身上，它的活动报告了它们探索环境时的实际HD，在睡眠的小鼠中，它们的虚拟HD报告了它们的活动。我们发现，快速眼动睡眠中快速眼球运动的方向和幅度揭示了虚拟高清正在进行的变化的方向和幅度。因此，快速的眼球运动揭示了快速眼动睡眠虚拟世界中的视线转移，从而为了解睡眠大脑的认知过程提供了一个窗口。睡眠包括以快速眼动(REM)为特征的阶段，众所周知，这与做梦有关。但是，这些眼球运动与睡眠状态下的意识内容有关吗？Senzai和Scanziani记录了小鼠在清醒和睡眠期间丘脑前背核中的头部方向细胞(见de Zeeuw和Canto的观点)。快速眼球运动的方向和幅度编码了小鼠在快速眼动睡眠期间在虚拟环境中的方向和幅度。使用跳动的眼球运动，可以分别预测清醒和快速眼动睡眠中老鼠在真实和虚拟世界中的实际航向。-RPS
Since the discovery of rapid eye movement (REM) sleep, the nature of the eye movements that characterize this sleep phase has remained elusive. Do they reveal gaze shifts in the virtual environment of dreams or simply reflect random brainstem activity? We harnessed the head direction (HD) system of the mouse thalamus, a neuronal population whose activity reports, in awake mice, their actual HD as they explore their environment and, in sleeping mice, their virtual HD. We discovered that the direction and amplitude of rapid eye movements during REM sleep reveal the direction and amplitude of the ongoing changes in virtual HD. Thus, rapid eye movements disclose gaze shifts in the virtual world of REM sleep, thereby providing a window into the cognitive processes of the sleeping brain. Sleep includes phases characterized by rapid eye movement (REM) that were known to be associated with dreaming. But are these eye movements related to the contents of consciousness in that sleep state? Senzai and Scanziani recorded head direction cells in the anterior dorsal nucleus of the thalamus in mice during wake and sleep (see the Perspective by De Zeeuw and Canto). The direction and amplitude of rapid eye movements encoded the direction and amplitude of the heading of mice in their virtual environment during REM sleep. It was possible to predict the actual heading in the real and virtual world of the mice during wake and REM sleep, respectively, using saccadic eye movements. —PRS
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