Gut-resident microorganisms and their genes are associated with cognition and neuroanatomy in children.
Gut-resident microorganisms and their genes are associated with cognition and neuroanatomy in children.
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DOI：
10.1126/sciadv.adi0497
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发表时间：
2023-12-22
期刊：
影响因子：
13.6
通讯作者：
Klepac-Ceraj, Vanja
中科院分区：
文献类型：
--
作者：
Bonham, Kevin S.;Bottino, Guilherme Fahur;McCann, Shelley Hoeft;Beauchemin, Jennifer;Weisse, Elizabeth;Barry, Fatoumata;Lorente, Rosa Cano;Huttenhower, Curtis;Bruchhage, Muriel;D'Sa, Viren;Deoni, Sean;Klepac-Ceraj, Vanja
新出现的证据表明肠道微生物代谢与神经发育障碍有关，但其对典型神经发育的影响尚未得到详细探讨。我们研究了381名健康儿童的微生物群与神经解剖学和认知之间的关系，表明微生物群和基因的差异与整体认知功能和大脑区域的大小有关。通过统计和机器学习模型的结合，研究人员发现，在认知功能得分较高的儿童中，包括肥胖阿利斯特（Alistipes obesi）、韦氏蓝球菌（Blautia weexlerae）和侏儒瘤球菌（Ruminococcus gnavus）在内的物种丰富或减少。短链脂肪酸的微生物代谢也与认知功能有关。此外，机器模型能够从微生物剖面中预测大脑区域的体积，并且在预测认知功能方面很重要的分类群对于预测个体大脑区域和认知功能的特定亚尺度也很重要。这些发现为神经认知发育提供了潜在的生物标志物，并可能为早期发现和干预目标的发展提供了可能。婴儿和儿童肠道中复杂的微生物群落可能会影响他们的大脑发育。
Emerging evidence implicates gut microbial metabolism in neurodevelopmental disorders, but its influence on typical neurodevelopment has not been explored in detail. We investigated the relationship between the microbiome and neuroanatomy and cognition of 381 healthy children, demonstrating that differences in microbial taxa and genes are associated with overall cognitive function and the size of brain regions. Using a combination of statistical and machine learning models, we showed that species including Alistipes obesi, Blautia wexlerae, and Ruminococcus gnavus were enriched or depleted in children with higher cognitive function scores. Microbial metabolism of short-chain fatty acids was also associated with cognitive function. In addition, machine models were able to predict the volume of brain regions from microbial profiles, and taxa that were important in predicting cognitive function were also important for predicting individual brain regions and specific subscales of cognitive function. These findings provide potential biomarkers of neurocognitive development and may enable development of targets for early detection and intervention. The complex community of microorganisms living in the guts of infants and children may affect how their brains develop.
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