Measurement of cardiovascular function using a novel view-sharing PET reconstruction method and tracer kinetic analysis.
Measurement of cardiovascular function using a novel view-sharing PET reconstruction method and tracer kinetic analysis.
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DOI：
10.1186/s40658-016-0161-4
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发表时间：
2016-12
期刊：
影响因子：
4
通讯作者：
Hutchins GD
中科院分区：
文献类型：
--
作者：
Territo PR;Riley AA;McCarthy BP;Hutchins GD
PET仪器的最新进展使小动物心血管功能的无创评估成为现实。大多数小动物PET系统使用固定式检测器门架，从而提供高时间分辨率的心功能成像。当需要高时间分辨率成像时，采用旋转龙门设计的最大化空间分辨率和检测灵敏度的系统是次优的。为了克服这一限制，目前的工作开发了一种新的视图共享数据分析方案，适用于动态心脏PET成像，使用18F-NaF作为示踪剂和示踪剂动力学模型分析。该方案在大鼠心血管功能模型中进行了测试，其中心输出量的直接跨音速流量测量与新模型之间的关系高度相关（f(x) = 1.0216x−24.233,R = 0.9158, p < 0.001）。同样，衍生的脑卒中量测量也与当前方法高度相关（f(x) = 0.9655x - 0.0428, R = 0.9453, p < 0.001）。治疗组脑卒中量增加（0.32±0.07 ml, p = 0.003, n = 4），心率降低（- 155±7.1次/min， p < 0.001, n = 4），心输出量降低（- 75.9±23.0 ml/kg min, p = 0.01, n = 4）。这些发现表明，新的sinogram binning和动力学建模方法产生了可靠的心功能测量方法，适用于心血管功能的纵向监测。
Recent advancements in PET instrumentation have made the non-invasive assessment of cardiovascular function in small animals a reality. The majority of small animal PET systems use stationary detector gantries, thus affording high temporal resolution imaging of cardiac function. Systems designed to maximize spatial resolution and detection sensitivity employing rotating gantry designs are suboptimal when high temporal resolution imaging is needed. To overcome this limitation, the current work developed a novel view-sharing data analysis scheme suitable for dynamic cardiac PET imaging using 18F-NaF as the tracer and tracer kinetic model analysis. This scheme was tested in a rat model of cardiovascular function where the relationship between direct transonic flow measures of cardiac output were highly correlated (f(x) = 1.0216x − 24.233, R = 0.9158, p < 0.001) with the new model. Similarly, derived measures of stroke volume were also highly correlated (f(x) = 0.9655x − 0.0428, R = 0.9453, p < 0.001) with the current approach. Administration of xylazine caused a statistically significant increase in stroke volume (0.32 ± 0.07 ml, p = 0.003, n = 4) and a significant decrease in both heart rate (−155 ± 7.1 beats/min, p < 0.001, n = 4) and cardiac output (−75.9 ± 23.0 ml/kg min, p = 0.01, n = 4). These findings suggest that the new sinogram binning and kinetic modeling methods produce reliable cardiac function measures suitable for longitudinal monitoring of cardiovascular function.
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