Structure-based antigen design: a strategy for next generation vaccines.
Structure-based antigen design: a strategy for next generation vaccines.
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DOI：
10.1016/j.tibtech.2008.08.002
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发表时间：
2008-12
影响因子：
17.3
通讯作者：
Rappuoli R
中科院分区：
文献类型：
--
作者：
Dormitzer PR;Ulmer JB;Rappuoli R
疫苗的设计正从单纯免疫向保护性免疫目标的日益合理的呈现发展。然而，大多数当前的疫苗抗原基本上是病原体的天然大分子。这些分子适应于逃避而不是诱导免疫。高分辨率结构揭示了中和抗体识别的静电表面和这些表面下的结构，从而确定哪些亚结构必须保持完整，哪些可以改变以优化生化和免疫性能。有了详细的结构信息，我们可以设计出更稳定、更均匀、更高效的优化抗原，使免疫接种更实用、更实惠。了解免疫原性和免疫优势的结构基础将使我们能够提高疫苗的有效性，扩大疫苗可预防疾病的范围。
Vaccine design is progressing from empiricism towards the increasingly rational presentation of the targets of protective immunity. Nevertheless, most current vaccine antigens are essentially the native macromolecules of pathogens. These molecules are adapted to evade, not induce, immunity. High resolution structures reveal the electrostatic surfaces recognized by neutralizing antibodies and the architectures underlying these surfaces, thereby identifying which substructures must be left intact and which can be changed to optimize biochemical and immunologic performance. Armed with detailed structural information, we can engineer optimized antigens that are more stable, homogeneous, and efficiently produced, making immunization more practical and affordable. Understanding the structural basis for immunogenicity and immunodominance will allow us to improve vaccine efficacy and broaden the range of vaccine-preventable diseases.
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影响因子：
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影响因子：
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