Contralateral Delay Activity Tracks Fluctuations in Working Memory Performance.
Contralateral Delay Activity Tracks Fluctuations in Working Memory Performance.
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DOI：
10.1162/jocn_a_01233
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发表时间：
2018-09
影响因子：
3.2
通讯作者：
Vogel EK
中科院分区：
文献类型：
--
作者：
Adam KCS;Robison MK;Vogel EK
对侧延迟活动（CDA）等工作记忆存储的神经测量方法是研究工作记忆的有力工具。CDA振幅对工作记忆负荷敏感，在已知行为极限处达到渐近线，并预测个体容量差异。然而，一个悬而未决的问题是，负荷的神经测量是否也能追踪每次试验的表现波动。本研究采用全报告工作记忆任务来检验CDA振幅与工作记忆表现之间的关系。如果工作记忆失败是由于基于决策的错误和检索失败，当负载保持不变时，CDA振幅将无法区分良好和较差的性能试验。如果在存储过程中出现故障，则CDA振幅应跟踪工作记忆负载和逐个试验的性能。正如预期的那样，CDA振幅跟踪负载（实验1），在三个项目上达到渐近线。在实验2中，我们跟踪每个试验性能的波动。与低绩效试验相比，高绩效试验的CDA振幅更大（更负），这表明绩效的波动与项目的成功存储有关。在工作记忆失败期间，参与者将注意力导向屏幕的正确一侧（侧化P1），并在延迟期间保持对正确一侧的隐蔽注意（侧化阿尔法功率抑制）。尽管注意导向得以保留，但我们发现的损伤与工作记忆容量个体差异的执行注意理论一致；执行控制的波动（以审判前额波功率为指标）可能是存储失败的原因。
Neural measures of working memory storage, such as the contralateral delay activity (CDA), are powerful tools in working memory research. CDA amplitude is sensitive to working memory load, reaches an asymptote at known behavioral limits, and predicts individual differences in capacity. An open question, however, is whether neural measures of load also track trial-bytrial fluctuations in performance. Here, we used a whole-report working memory task to test the relationship between CDA amplitude and working memory performance. If working memory failures are due to decision-based errors and retrieval failures, CDA amplitude would not differentiate good and poor performance trials when load is held constant. If failures arise during storage, then CDA amplitude should track both working memory load and trial-by-trial performance. As expected, CDA amplitude tracked load (Experiment 1), reaching an asymptote at three items. In Experiment 2, we tracked fluctuations in trial-by-trial performance. CDA amplitude was larger (more negative) for high-performance trials compared with low-performance trials, suggesting that fluctuations in performance were related to the successful storage of items. During working memory failures, participants oriented their attention to the correct side of the screen (lateralized P1) and maintained covert attention to the correct side during the delay period (lateralized alpha power suppression). Despite the preservation of attentional orienting, we found impairments consistent with an executive attention theory of individual differences in working memory capacity; fluctuations in executive control (indexed by pretrial frontal theta power) may be to blame for storage failures.
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