Donor-acceptor structured photothermal COFs for enhanced starvation therapy
Donor-acceptor structured photothermal COFs for enhanced starvation therapy
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用于增强饥饿疗法的供体-受体结构光热COF
DOI：
10.1016/j.cej.2022.135963
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发表时间：
2022-03
影响因子：
15.1
通讯作者：
Zhe Liu
中科院分区：
文献类型：
--
作者：
Shaohua Song;D;an Wang;Kai Zhao;Yuting Wu;Pei Zhang;Jinfeng Liu;Ge Yang;Peiwei Gong;Zhe Liu
由于共价有机框架（COFs）的不溶性和易聚集，将足够的葡萄糖氧化酶（GOX）靶向递送到肿瘤细胞中仍然是一个巨大的挑战。本文提出了一种制备纳米给受体（D-A）结构COFs的有效方法，该方法具有尺寸可调、长时间的水分散性和特殊的选择性。设计的D-A结构为有效的载流子输运提供了途径和通道，使COFs具有优异的光热性能，大大提高了饥饿治疗效率。交联晶体的大表面积和孔隙率使其具有较高的GOX负载能力，进一步的生物分子表面修饰使其具有胶体样水稳定性和靶向选择性。所有这些良好的特性保证了体外肿瘤消融比单一治疗更好，并且也取得了突出的抗迁移效果。详细的细胞凋亡研究表明，联合治疗有效产生活性氧，并通过内源性线粒体凋亡途径和Caspase-3激活过程诱导细胞凋亡，最终使癌细胞对能量供应不足和高温更加敏感。本工作开发了一种新的策略来合成具有良好分散性的D-A结构光热COFs，并大大提高了饥饿治疗的效果，而无需额外使用化学药物。
Targeted delivery of adequate glucose oxidase (GOX) into tumor cells by covalent organic frameworks (COFs) remains a great challenge due to their insolubility and easy aggregation. Herein, an effective strategy to synthesize nanosized donor–acceptor (D-A) structured COFs with tunable sizes, long-time water-dispersibility and special selectivity was developed. Designed D-A structure provided pathways and channels for effective charge carriers transport, and this endowed COFs with excellent photothermal property to greatly enhance starvation therapy efficiency. Large surface area and porosity in the cross-linked crystal allowed high GOX loading capacity, and further surface modification with biomolecules made it possess colloid-like water stability and targeted selectivity. All these good properties guaranteed much betterin vivoandin vitrotumor ablation than single therapy, and outstanding anti-migration results were also achieved. Detailed cell apoptosis study indicated the combined therapy effectively produced reactive oxygen species, and apoptosis was induced by endogenous mitochondrial apoptosis pathway and Caspase-3 activation process, finally making cancer cells more sensitive to inadequate energy supply and high temperature. This work developed a new strategy to synthesize D-A structured photothermal COFs with good dispersibility and greatly enhance starvation therapy without any additional use of chemical drugs.
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