Family history of Alzheimer's disease and hippocampal structure in healthy people.
Family history of Alzheimer's disease and hippocampal structure in healthy people.
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DOI：
10.1176/appi.ajp.2010.09111575
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发表时间：
2010-11
期刊：
影响因子：
--
通讯作者：
Bookheimer SY
中科院分区：
文献类型：
--
作者：
Donix M;Burggren AC;Suthana NA;Siddarth P;Ekstrom AD;Krupa AK;Jones M;Martin-Harris L;Ercoli LM;Miller KJ;Small GW;Bookheimer SY
在老年痴呆症（生命晚期痴呆的主要病因）发病前数年，大脑结构就会出现变化。确定这种症状前大脑变化的风险因素可能有助于确定未来预防治疗试验的候选对象。除了载脂蛋白E基因（APOE - 4）的e4等位基因这一已知的主要遗传风险因素外，阿尔茨海默病家族史也会增加患病风险，这反映了尚未确定的遗传风险，或许还有非遗传风险。作者研究了APOE - 4基因型和家族史风险对无认知障碍志愿者内侧颞叶亚区皮质厚度的影响。
对26名至少有一名一级亲属患有阿尔茨海默病的受试者（APOE - 4携带者：N = 13；非携带者：N = 13）以及25名无此风险因素的受试者（APOE - 4携带者：N = 12；非携带者：N = 13）进行了高分辨率磁共振成像（MRI）和皮质展开方法检查。所有受试者（平均年龄：62.3岁[标准差 = 10.7]；范围 = 38 - 86岁）认知健康。
阿尔茨海默病家族史和APOE - 4状态与内嗅区、下托以及相邻的内侧颞叶亚区皮质变薄有关。尽管这些关联是累加的，但阿尔茨海默病家族史对皮质厚度独特方差的解释比例大于APOE - 4携带者状态。
APOE - 4携带者状态和阿尔茨海默病家族史与海马皮质变薄独立相关，并具有累加作用。
Structural brain changes appear years before the onset of Alzheimer’s disease, the leading cause of dementia late in life. Determining risk factors for such presymptomatic brain changes may assist in identifying candidates for future prevention treatment trials. In addition to the e4 allele of the apolipoprotein E gene (APOE-4), the major known genetic risk factor, a family history of Alzheimer’s disease also increases the risk to develop the disease, reflecting yet unidentified genetic and, perhaps, nongenetic risks. The authors investigated the influence of APOE-4 genotype and family history risks on cortical thickness in medial temporal lobe subregions among volunteers without cognitive impairment. High-resolution magnetic resonance imaging (MRI) and a cortical unfolding method were performed on 26 subjects (APOE-4 carriers: N =13; noncarriers: N =13) with at least one first-degree relative with Alzheimer’s disease and 25 subjects (APOE-4 carriers: N =12; noncarriers: N =13) without this risk factor. All subjects (mean age: 62.3 years [SD=10.7]; range=38–86 years) were cognitively healthy. Family history of Alzheimer’s disease and APOE-4 status were associated with a thinner cortex in the entorhinal region, subiculum, and adjacent medial temporal lobe subfields. Although these associations were additive, family history of Alzheimer’s disease explained a greater proportion of the unique variance in cortical thickness than APOE-4 carrier status. APOE-4 carrier status and family history of Alzheimer’s disease are independently associated with and contribute additively to hippocampal cortical thinning.
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影响因子：
3.5
作者：
Mueller, Susanne G.;Weiner, Michael W.
通讯作者：
Weiner, Michael W.
影响因子：
2.1
作者：
Risacher SL;Saykin AJ;West JD;Shen L;Firpi HA;McDonald BC;Alzheimer's Disease Neuroimaging Initiative (ADNI)
通讯作者：
Alzheimer's Disease Neuroimaging Initiative (ADNI)
DOI：
10.1073/pnas.0705036104
发表时间：
2007-11-27
影响因子：
11.1
作者：
Mosconi, Lisa;Brys, Miroslaw;de Leon, Mony J.
通讯作者：
de Leon, Mony J.
影响因子：
9.8
作者：
Daw, EW;Payami, H;Wijsman, EM
通讯作者：
Wijsman, EM
影响因子：
9.9
作者：
den Heijer, T;Oudkerk, M;Breteler, MMB
通讯作者：
Breteler, MMB