Serum growth differentiation factor 11 is closely related to metabolic syndrome in a Chinese cohort.
Serum growth differentiation factor 11 is closely related to metabolic syndrome in a Chinese cohort.
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血清生长分化因子11与中国队列中的代谢综合征密切相关。
DOI：
10.1111/jdi.13337
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发表时间：
2021-03
影响因子：
3.2
通讯作者：
Jia W
中科院分区：
文献类型：
--
作者：
Xu B;Huang Y;Zhang R;Tang M;He Z;Jin L;Zong Y;Hu C;Jia W
尽管生长分化因子11（GDF 11）在年龄相关疾病中的作用越来越受到关注，但其临床意义-特别是代谢性疾病-仍不清楚。因此，我们评估了中国人群中血清GDF 11水平与代谢紊乱之间的关联。共纳入来自上海Nicheng队列研究的381名个体。除了人体测量、实验室和超声检查测量外，还通过酶联免疫吸附试验测量了GDF 11的血清浓度。循环GDF 11浓度随年龄变化无变化（r =-0.064，P = 0.210），但与体重指数、腰围和无脂肪质量指数呈负相关（均P < 0.05）。相关性分析显示，在调整性别、年龄和体重指数后，GDF 11浓度降低伴随舒张压、空腹和2 h血糖、甘油三酯和低密度脂蛋白胆固醇升高，而天冬氨酸转氨酶和游离甲状腺素的变化与GDF 11一致（均P < 0.05）。此外，糖代谢异常、体重指数和/或肝脏脂肪蓄积的人群，尤其是男性，GDF 11的血清水平较低（P < 0.05）;当按GDF 11水平四分位数分层时，发现代谢综合征发病率沿着GDF 11循环下降（P趋势<0.001）。Logistic回归分析显示，血清GDF 11水平与代谢综合征的存在独立相关（比值比0.665，95%可信区间0.510-0.867，P = 0.003）。我们证实GDF 11是一种内分泌因子，在多代谢过程中发挥重要作用，是中国人群（尤其是男性）代谢综合征的一个指标。GDF 11是一种内分泌因子，在多种代谢过程中发挥重要作用。GDF 11是中国人群中MetS的指标。
Despite increasing interest in growth differentiation factor 11 (GDF11) based on its involvement in age‐related disorders, clinical implications – especially for metabolic diseases – remain unclear. Therefore, we assessed the association between serum GDF11 levels and metabolic disturbance in the Chinese population. A total of 381 individuals from the Shanghai Nicheng Cohort Study were included. In addition to anthropometry, laboratory and ultrasonography measurements, serum concentrations of GDF11 were measured by enzyme‐linked immunosorbent assay. Circulating GDF11 concentrations were unchanged with age (r = –0.064, P = 0.210), but showed an inverse relationship to body mass index, waist circumference and fat‐free mass index (all P < 0.05). Correlation analysis showed decreased GDF11 concentrations accompanied by elevated diastolic blood pressure, fasting and 2‐h plasma glucose, triglycerides, and low‐density lipoprotein cholesterol after adjusting for sex, age and body mass index, whereas variations in aspartate aminotransferase and free thyroxine were consistent with GDF11 (all P < 0.05). Furthermore, people, especially men, with abnormal glycometabolism, body mass index and/or fat accumulation in the liver had lower serum levels of GDF11 (P < 0.05); an increase in metabolic syndrome morbidity along with the circulatory decline of GDF11 was found when stratified by GDF11‐level quartiles (P‐trend <0.001). Logistic regression showed that serum GDF11 levels were independently correlated with the presence of metabolic syndrome (odds ratio 0.665, 95% confidence interval 0.510–0.867, P = 0.003). We confirmed GDF11 as an endocrine factor playing a significant role in multiple metabolic processes and an indicator of metabolic syndrome in the Chinese population, particularly in males. GDF11 is an endocrine factor which playing a significant role in multiple metabolic processes. GDF11 is an indicator of MetS in the Chinese population.
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影响因子：
29
作者：
Egerman MA;Cadena SM;Gilbert JA;Meyer A;Nelson HN;Swalley SE;Mallozzi C;Jacobi C;Jennings LL;Clay I;Laurent G;Ma S;Brachat S;Lach-Trifilieff E;Shavlakadze T;Trendelenburg AU;Brack AS;Glass DJ
通讯作者：
Glass DJ
影响因子：
5.2
作者：
Anon-Hidalgo, Juan;Catalan, Victoria;Gomez-Ambrosi, Javier
通讯作者：
Gomez-Ambrosi, Javier
影响因子：
3.9
作者：
Anon-Hidalgo, Juan;Catalan, Victoria;Gomez-Ambrosi, Javier
通讯作者：
Gomez-Ambrosi, Javier
GDF11 通过改善胰岛 β 细胞功能和存活来减缓 2 型糖尿病的发展
影响因子：
7.7
作者：
Li, Huan;Li, Yixiang;Xiang, Guangda
通讯作者：
Xiang, Guangda
重新关注人血清中GDF11水平波动与体检指标的关系
DOI：
10.1093/gerona/glz129
发表时间：
2020-06-01
影响因子：
5.1
作者：
Liang, Xiaolin;Dou, Xiaowei;Li, Quanyang
通讯作者：
Li, Quanyang