Neural basis of implicit memory for socio-emotional information in schizophrenia.
Neural basis of implicit memory for socio-emotional information in schizophrenia.
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DOI：
10.1016/j.psychres.2012.10.005
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发表时间：
2013-04-30
影响因子：
11.3
通讯作者：
Deutsch, Stephen I.
中科院分区：
文献类型：
--
作者：
Schwartz, Barbara L.;Vaidya, Chandan J.;Shook, Devon;Deutsch, Stephen I.
精神分裂症患者在处理社会信号（如情绪的面部表情）方面受损。感知面部表情是一个复杂的过程，它依赖于情感、认知和视觉处理区域的分布式神经网络。我们研究了重复启动，知觉学习的无意识形式，探索视觉知觉过程与精神分裂症患者的面部表情感知。功能性磁共振成像（fMRI）也被用来探测腹侧通路中面孔反应区域对重复刺激的敏感性。受试者看到了新的和重复的面孔块显示恐惧的表情和中性的表情，并确定每个面孔是男性或女性。性别的决定是更快的重复编码相对于初始编码的面孔，表明显着的面部表情启动。精神分裂症患者的启动是正常的，但正如预期的那样，对表情的识别记忆受损。神经影像学研究结果显示，无论面部表情如何，患者左侧梭状回的启动相关激活减少。研究结果表明，精神分裂症患者改变了腹侧视觉处理流区域的神经敏感性，这些区域是物体和面孔早期感知学习的基础。
Individuals with schizophrenia are impaired in processing social signals such as facial expressions of emotion. Perceiving facial expressions is a complex process that depends on a distributed neural network of regions involved in affective, cognitive, and visual processing. We examined repetition priming, a non-conscious form of perceptual learning, to explore the visual-perceptual processes associated with perceiving facial expression in people with schizophrenia. Functional magnetic resonance imaging (fMRI) was also employed to probe the sensitivity of face-responsive regions in the ventral pathway to the repetition of stimuli. Subjects viewed blocks of novel and repeated faces displaying fear expressions and neutral expressions and identified each face as male or female. Gender decisions were faster for repeated encoding relative to initial encoding of faces, indicating significant priming for facial expressions. Priming was normal in schizophrenia patients, but, as expected, recognition memory for the expressions was impaired. Neuroimaging findings showed that priming-related activation for patients was reduced in the left fusiform gyrus, relative to controls, regardless of facial expression. The findings suggest that schizophrenia patients have altered neural sensitivity in regions of the ventral visual processing stream that underlie early perceptual learning of objects and faces.
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DOI：
10.1037/0278-7393.11.3.501
发表时间：
1985-01-01
影响因子：
2.6
作者：
GRAF, P;SCHACTER, DL
通讯作者：
SCHACTER, DL
DOI：
10.1037//0278-7393.26.5.1198
发表时间：
2000-09-01
影响因子：
2.6
作者：
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通讯作者：
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影响因子：
3.2
作者：
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通讯作者：
Anderson, AW
影响因子：
11.3
作者：
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通讯作者：
Fuentes, Inma
影响因子：
2.3
作者：
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通讯作者：
Kubicki, Marek