Intravenous immunoglobulin response in new-onset refractory status epilepticus (NORSE) COVID-19 adult patients.
Intravenous immunoglobulin response in new-onset refractory status epilepticus (NORSE) COVID-19 adult patients.
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DOI：
10.1007/s00415-021-10468-y
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发表时间：
2021-10
影响因子：
6
通讯作者：
Buoite Stella A
中科院分区：
文献类型：
--
作者：
Manganotti P;Furlanis G;Ajčević M;Moras C;Bonzi L;Pesavento V;Buoite Stella A
神经系统表现在COVID-19患者中可能很常见。它们可能包括几种综合征，如提示自身免疫异常反应，这可能导致脑炎和新发难治性癫痫持续状态（NORSE）。由于相关的快速恶化和不良后果，必须迅速识别此类病例并开始最适当的治疗。本病例系列描述了两名进入大学医院的成人患者，他们对新型冠状病毒2019 （SARS-CoV-2）感染呈阳性，并出现耐药性癫痫持续状态。两例患者均进行了早期脑电图（EEG）评估，显示病理性脑电图模式，其特征为普遍减慢，节律性活动和持续的癫痫发作活动。疑似自身免疫性病因，可能由SARS-CoV-2感染引发，鼓励对可能的自身免疫性脑炎诊断进行快速检查。治疗方法包括静脉注射免疫球蛋白0.4 g/kg，分别在5天和10天后癫痫发作完全消退，无不良反应，随后脑电图模式正常化。
Neurological manifestations may be common in COVID-19 patients. They may include several syndromes, such as a suggested autoimmune abnormal response, which may result in encephalitis and new-onset refractory status epilepticus (NORSE). Quickly recognizing such cases and starting the most appropriate therapy is mandatory due to the related rapid worsening and bad outcomes. This case series describes two adult patients admitted to the university hospital and positive to novel coronavirus 2019 (SARS-CoV-2) infection who developed drug-resistant status epilepticus. Both patients underwent early electroencephalography (EEG) assessment, which showed a pathological EEG pattern characterized by general slowing, rhythmic activity and continuous epileptic paroxysmal activity. A suspected autoimmune etiology, potentially triggered by SARS-CoV-2 infection, encouraged a rapid work-up for a possible autoimmune encephalitis diagnosis. Therapeutic approach included the administration of 0.4 g/kg intravenous immunoglobulin, which resulted in a complete resolution of seizures after 5 and after 10 days, respectively, without adverse effects and followed by a normalization of the EEG patterns.
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影响因子：
3
作者：
Monti, Giulia;Giovannini, Giada;Meletti, Stefano
通讯作者：
Meletti, Stefano
影响因子：
3.2
作者：
Ajčević M;Furlanis G;Naccarato M;Miladinović A;Buoite Stella A;Caruso P;Cillotto T;Accardo A;Manganotti P
通讯作者：
Manganotti P
影响因子：
11.2
作者：
Sutter, Raoul;Hert, Lisa;Kuhle, Jens
通讯作者：
Kuhle, Jens
DOI：
10.1038/s41582-020-00453-w
发表时间：
2021-03
期刊：
Nature reviews. Neurology
影响因子：
--
作者：
Solomon T
通讯作者：
Solomon T
DOI：
10.1016/j.seizure.2020.10.014
发表时间：
2020-12
期刊：
Seizure
影响因子：
--
作者：
Antony AR;Haneef Z
通讯作者：
Haneef Z