The role of the medial prefrontal cortex in trace fear extinction.
The role of the medial prefrontal cortex in trace fear extinction.
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DOI：
10.1101/lm.036517.114
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发表时间：
2014-01
期刊：
影响因子：
--
通讯作者：
Helmstetter FJ
中科院分区：
文献类型：
--
作者：
Kwapis JL;Jarome TJ;Helmstetter FJ
延迟恐惧条件反射的消失依赖于一个神经回路，这个回路受到了很多关注，并且相对来说定义得很好。然而，这个既定的回路是否也支持更复杂的关联的灭绝，尚不清楚。痕迹恐惧条件反射是复杂关系学习的一个更好的模型，然而支持这种记忆消退的回路却很少受到关注。最近的研究表明，与延迟消退相比，消除痕量恐惧需要不同的神经回路;消除痕量恐惧需要压后皮质的参与，但不需要杏仁核，正如先前的研究所指出的那样。在这里，我们测试的作用，前边缘和边缘下区内侧前额叶皮层的痕迹和延迟恐惧消退，通过阻断NMDA受体在灭绝学习。我们发现，前边缘皮层是必要的痕迹，但不是延迟恐惧灭绝，而边缘下皮层参与这两种类型的灭绝。这些结果是一致的想法，跟踪恐惧协会需要可塑性在多个皮层区域成功灭绝。此外，无论动物最初是否接受过跟踪或延迟条件反射训练，边缘下皮层似乎都在灭绝中发挥作用。总之，我们的研究结果提供了关于支持跟踪和延迟恐惧消退的神经回路如何不同的新信息。
The extinction of delay fear conditioning relies on a neural circuit that has received much attention and is relatively well defined. Whether this established circuit also supports the extinction of more complex associations, however, is unclear. Trace fear conditioning is a better model of complex relational learning, yet the circuit that supports extinction of this memory has received very little attention. Recent research has indicated that trace fear extinction requires a different neural circuit than delay extinction; trace extinction requires the participation of the retrosplenial cortex, but not the amygdala, as noted in a previous study. Here, we tested the roles of the prelimbic and infralimbic regions of the medial prefrontal cortex in trace and delay fear extinction by blocking NMDA receptors during extinction learning. We found that the prelimbic cortex is necessary for trace, but not for delay fear extinction, whereas the infralimbic cortex is involved in both types of extinction. These results are consistent with the idea that trace fear associations require plasticity in multiple cortical areas for successful extinction. Further, the infralimbic cortex appears to play a role in extinction regardless of whether the animal was initially trained in trace or delay conditioning. Together, our results provide new information about how the neural circuits supporting trace and delay fear extinction differ.
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影响因子：
1.9
作者：
Bailey, DJ;Kim, JJ;Helmstetter, FJ
通讯作者：
Helmstetter, FJ
影响因子：
56.9
作者：
Berman, DE;Dudai, Y
通讯作者：
Dudai, Y
影响因子：
2
作者：
Gilmartin, Marieke R.;Helmstetter, Fred J.
通讯作者：
Helmstetter, Fred J.
影响因子：
3.4
作者：
Davis, M
通讯作者：
Davis, M
DOI：
10.1073/pnas.2132313100
发表时间：
2003-10-28
影响因子：
11.1
作者：
Han, CJ;O'Tuathaigh, CM;Anderson, DJ
通讯作者：
Anderson, DJ