Patterns of spinal sensory-motor connectivity prescribed by a dorsoventral positional template.
Patterns of spinal sensory-motor connectivity prescribed by a dorsoventral positional template.
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DOI：
10.1016/j.cell.2011.10.012
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发表时间：
2011-10-28
期刊：
影响因子：
64.5
通讯作者：
Jessell TM
中科院分区：
文献类型：
--
作者：
Sürmeli G;Akay T;Ippolito GC;Tucker PW;Jessell TM
脊髓中的感觉运动回路具有协调运动行为的精细特异性，但指导感觉与其运动神经元伙伴的连接的机制仍不清楚。已知脊髓中运动池的背腹稳定位置与其肢体中肌肉目标的远端到近端位置相匹配，但运动神经元定位不变的意义尚不清楚。对 FoxP1 突变小鼠的感觉-运动连接模式的分析表明，感觉-运动连接的最终模式是由感觉轴突投射到脊髓的离散背腹域而启动的，而不考虑运动神经元亚型，或者实际上，运动神经元的存在。言外之意，运动神经元池的聚集和背腹稳定位置是感觉输入特异性模式的决定因素，从而决定了运动协调。
Sensory-motor circuits in the spinal cord are constructed with a fine specificity that coordinates motor behavior, but the mechanisms that direct sensory connections with their motor neuron partners remain unclear. The dorsoventral settling position of motor pools in the spinal cord is known to match the distal-to-proximal position of their muscle targets in the limb, but the significance of invariant motor neuron positioning is unknown. An analysis of sensory-motor connectivity patterns in FoxP1 mutant mice, where motor neuron position has been scrambled, shows that the final pattern of sensory-motor connections is initiated by the projection of sensory axons to discrete dorsoventral domains of the spinal cord without regard for motor neuron subtype, or indeed, the presence of motor neurons. By implication, the clustering and dorsoventral settling position of motor neuron pools serves as a determinant of the pattern of sensory input specificity, and thus motor coordination.
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