Predictors of early adulthood quality of life in children with obsessive-compulsive disorder.
Predictors of early adulthood quality of life in children with obsessive-compulsive disorder.
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DOI：
10.1007/s00127-010-0194-2
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发表时间：
2011-04
影响因子：
4.4
通讯作者：
Leckman, James F.
中科院分区：
文献类型：
--
作者：
Palermo, Sean D.;Bloch, Michael H.;Craiglow, Brittany;Landeros-Weisenberger, Angeli;Dombrowski, Philip A.;Panza, Kaitlyn;Smith, Megan E.;Peterson, Bradley S.;Leckman, James F.
本研究的目的是确定强迫症(OCD)儿童成年期早期生活质量(QOL)的儿童期临床预测因子。对62名符合条件的强迫症儿童中的36名进行了纵向队列研究，在儿童基线(平均年龄：12.1±2.1，范围：8.0-15.8)时进行了一次访谈，并在成年期早期进行了一次访谈，平均随访间隔为9年。采用功能受损工具(LIFT-RIFT)的纵向间隔追踪评估范围测量成年后的生活质量。42%的儿童在成年早期经历了强迫症症状的缓解。强迫症似乎对生活质量的人际关系和工作领域造成了最大的损害。成年期早期的生活质量与强迫症和焦虑症状的严重程度显著相关。儿童时期的主要囤积症状预示着成年后生活质量差。儿童期和成年期禁忌思维维度的症状增加与成年后生活质量的改善有关。成年后强迫症症状缓解的儿童在生活质量上没有残留损害的证据，而成年后强迫症症状未能缓解的儿童在生活质量上至多表现出轻微的损害。童年时的囤积症状似乎不仅预示着强迫症症状的持续存在，而且还预示着成年初期生活质量的下降。
The goal of this study was to determine childhood clinical predictors of quality of life (QoL) in early adulthood in children with Obsessive-Compulsive Disorder (OCD). A longitudinal cohort study was conducted with 36(out of 62 eligible) children with OCD, interviewed once at childhood baseline (mean age: 12.1±2.1, range: 8.0 – 15.8), and again in early adulthood after an average follow-up interval of 9 years. QoL was measured in adulthood with the Longitudinal Interval Follow-up Evaluation Range of Impaired Functioning Tool (LIFE-RIFT). Forty-two percent of children experienced a remission of OCD symptoms by early adulthood. OCD appeared to most strongly impair the interpersonal relationships and work domains of QoL. QoL and severity of OCD and anxiety symptoms were significantly associated in early adulthood. Primary hoarding symptoms in childhood predicted poor QoL in adulthood. Increased symptoms in the forbidden thoughts dimension in both childhood and adulthood were associated with improved adulthood QoL. Children for whom OCD symptoms remitted by adulthood showed no evidence of residual impairment in QoL, whereas children whose OCD symptoms failed to remit by adulthood showed at most mild impairment in QoL. Hoarding symptoms in childhood appear to portend not only the persistence of OCD symptoms but also poorer QoL in early adulthood.
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DOI：
10.1176/appi.ajp.2008.08020320
发表时间：
2008-12
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Bloch MH;Landeros-Weisenberger A;Rosario MC;Pittenger C;Leckman JF
通讯作者：
Leckman JF
影响因子：
22.8
作者：
Mataix-Cols, D;Marks, IM;Baer, L
通讯作者：
Baer, L
儿童和青少年强迫性症状维度的探索性分析：一项前瞻性后续研究。
影响因子：
4.4
作者：
Delorme, Richard;Bille, Arnaud;Betancur, Catalina;Mathieu, Flavie;Chabane, Nadia;Mouren-Simeoni, Marie Christine;Leboyer, Marion
通讯作者：
Leboyer, Marion
影响因子：
--
作者：
Kessler, RC;Berglund, P;Walters, EE
通讯作者：
Walters, EE
影响因子：
10.6
作者：
Freeman, Jennifer B.;Choate-Summers, Molly L.;Franklin, Martin E.
通讯作者：
Franklin, Martin E.