Systemic administration of follistatin288 increases muscle mass and reduces fat accumulation in mice.
Systemic administration of follistatin288 increases muscle mass and reduces fat accumulation in mice.
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DOI：
10.1038/srep02441
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发表时间：
2013
影响因子：
4.6
通讯作者：
Gangopadhyay, Samudra S.
中科院分区：
文献类型：
--
作者：
Gangopadhyay, Samudra S.
本研究描述了与小鼠每日皮下注射重组卵泡抑素288相关的生理反应。卵泡抑素288的这种全身给药增加了血清中的卵泡抑素水平，表明蛋白质进入循环。数据表明，也发生了剂量依赖性的瘦体重增加，以及肌肉质量增加，可能是由于肌肉纤维尺寸增加。治疗13周后，观察到代谢变化;此外，通过肌球蛋白重链重塑，肌纤维类型的转换也很明显，这意味着在分子水平上发生了变化。此外，肌肉量的增加与体脂量的显著减少有关。总之，这项研究提出了使用卵泡抑素288作为治疗肌肉萎缩性疾病和/或通过全身施用该蛋白质来限制脂肪积累的药剂的可能性。
The present study describes the physiological response associated with daily subcutaneous injection of mice with recombinant follistatin288. This systemic administration of follistatin288 increases the follistatin levels in serum, indicating that the protein enters the circulation. The data suggest that a dose-dependent increase in body lean mass also occurs, together with an increase in muscle mass, possibly as a result of an increase in the size of the muscle fibers. After thirteen weeks of treatment, metabolic changes were observed; additionally, the switching of muscle fiber types was also apparent through myosin heavy chain remodeling, implying that changes are occurring at the molecular level. Furthermore, an increase in the muscle mass was associated with a significant decrease in the body fat mass. Overall, this study raises the possibility for the use of follistatin288 as an agent to treat muscle wasting diseases and/or to restrict fat accumulation by systemic administration of the protein.
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DOI：
10.1056/nejmoa1000485
发表时间：
2010-07-08
期刊：
The New England journal of medicine
影响因子：
--
作者：
Basaria S;Coviello AD;Travison TG;Storer TW;Farwell WR;Jette AM;Eder R;Tennstedt S;Ulloor J;Zhang A;Choong K;Lakshman KM;Mazer NA;Miciek R;Krasnoff J;Elmi A;Knapp PE;Brooks B;Appleman E;Aggarwal S;Bhasin G;Hede-Brierley L;Bhatia A;Collins L;LeBrasseur N;Fiore LD;Bhasin S
通讯作者：
Bhasin S
影响因子：
3.4
作者：
Bogdanovich, Sasha;Mcnally, Elizabeth M.;Khurana, Tejvir S.
通讯作者：
Khurana, Tejvir S.
DOI：
10.1006/bbrc.2000.2768
发表时间：
2000-05-27
影响因子：
3.1
作者：
Lucas, CA;Kang, LHD;Hoh, JFY
通讯作者：
Hoh, JFY
影响因子：
--
作者：
POPE, HG;KATZ, DL
通讯作者：
KATZ, DL
影响因子：
2.5
作者：
LENDERS, JWM;DEMACKER, PNM;THIEN, T
通讯作者：
THIEN, T