Involvement of the cerebellum in migraine.
Involvement of the cerebellum in migraine.
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DOI：
10.3389/fnsys.2022.984406
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发表时间：
2022
影响因子：
3
通讯作者：
Sowers, Levi P.
中科院分区：
文献类型：
--
作者：
Wang, Mengya;Tutt, Joseph O.;Dorricott, Nicholas O.;Parker, Krystal L.;Russo, Andrew F.;Sowers, Levi P.
偏头痛是一种致残的神经系统疾病，以中度或重度头痛为特征，并伴有感觉异常，如畏光、异常性疼痛和眩晕。它影响了全世界大约15%的人。尽管目前偏头痛治疗取得了进展，但偏头痛的机制仍然难以捉摸。在中枢神经系统中，研究暗示小脑可能在偏头痛中起着重要的感觉整合作用。更具体地说，小脑已经被提出调节疼痛处理，成像研究已经揭示了偏头痛患者小脑的改变。本文综述了小脑与偏头痛相关的临床和临床前研究。我们将首先讨论小脑在疼痛调节中的作用，包括小脑神经元与疼痛相关大脑区域的连接。接下来，我们将回顾偏头痛患者的小脑症状和小脑影像学资料。最后，我们将强调神经肽降钙素基因相关肽（CGRP）在偏头痛症状中的可能作用，包括偏头痛动物模型的临床前小脑研究。
Migraine is a disabling neurological disease characterized by moderate or severe headaches and accompanied by sensory abnormalities, e.g., photophobia, allodynia, and vertigo. It affects approximately 15% of people worldwide. Despite advancements in current migraine therapeutics, mechanisms underlying migraine remain elusive. Within the central nervous system, studies have hinted that the cerebellum may play an important sensory integrative role in migraine. More specifically, the cerebellum has been proposed to modulate pain processing, and imaging studies have revealed cerebellar alterations in migraine patients. This review aims to summarize the clinical and preclinical studies that link the cerebellum to migraine. We will first discuss cerebellar roles in pain modulation, including cerebellar neuronal connections with pain-related brain regions. Next, we will review cerebellar symptoms and cerebellar imaging data in migraine patients. Lastly, we will highlight the possible roles of the neuropeptide calcitonin gene-related peptide (CGRP) in migraine symptoms, including preclinical cerebellar studies in animal models of migraine.
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影响因子：
7.4
作者：
Abad N;Rosenberg JT;Hike DC;Harrington MG;Grant SC
通讯作者：
Grant SC
影响因子：
3.5
作者：
Baumann, Oliver;Borra, Ronald J.;Bower, James M.;Cullen, Kathleen E.;Habas, Christophe;Ivry, Richard B.;Leggio, Maria;Mattingley, Jason B.;Molinari, Marco;Moulton, Eric A.;Paulin, Michael G.;Pavlova, Marina A.;Schmahmann, Jeremy D.;Sokolov, Arseny A.
通讯作者：
Sokolov, Arseny A.
影响因子：
3.5
作者：
Brighina, Filippo;Palermo, Antonio;Fierro, Brigida
通讯作者：
Fierro, Brigida
影响因子：
2.8
作者：
Bocci, Tommaso;Santarcangelo, Enrica;Sartucci, Ferdinando
通讯作者：
Sartucci, Ferdinando
DOI：
10.1523/jneurosci.2087-09.2009
发表时间：
2009-08-12
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bagnall MW;Zingg B;Sakatos A;Moghadam SH;Zeilhofer HU;du Lac S
通讯作者：
du Lac S