The Effects of Daytime Psilocybin Administration on Sleep: Implications for Antidepressant Action.
The Effects of Daytime Psilocybin Administration on Sleep: Implications for Antidepressant Action.
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白天psilocybin给药对睡眠的影响：对抗抑郁作用的影响。
DOI：
10.3389/fphar.2020.602590
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发表时间：
2020
影响因子：
5.6
通讯作者：
Horáček J
中科院分区：
文献类型：
--
作者：
Dudysová D;Janků K;Šmotek M;Saifutdinova E;Kopřivová J;Bušková J;Mander BA;Brunovský M;Zach P;Korčák J;Andrashko V;Viktorinová M;Tylš F;Bravermanová A;Froese T;Páleníček T;Horáček J
5-羟色胺激动剂裸盖菇素是一种具有抗抑郁潜力的迷幻药。睡眠可能与裸盖菇素的抗抑郁特性相互作用，就像其他抗抑郁药物一样，通过诱导神经可塑性。本研究的主要目的是评估裸盖菇素对裸盖菇素给药后夜间睡眠结构的影响。关于潜在的抗抑郁特性，我们假设裸盖菇素与其他经典抗抑郁药类似，会减少快速眼动（REM）睡眠并延长REM睡眠潜伏期。此外，我们还假设裸盖菇素会促进第一个睡眠周期中慢波活动（SWA）的表达，这是睡眠相关神经可塑性的标志。20名健康志愿者（10名女性，年龄28-53岁）接受了两次药物给药，psilocybin或安慰剂，采用随机双盲设计。分析了睡眠宏观结构的变化、第一个睡眠周期的SWA、非快速眼动（NREM）和REM睡眠中不同频率的整夜EEG谱功率以及主观睡眠指标的变化。结果显示，psilocybin给药后REM睡眠潜伏期延长，总体REM睡眠持续时间有减少的趋势。没有观察到NREM睡眠的变化。裸盖菇素没有影响脑电图功率谱在NREM或REM睡眠时，检查了整个晚上。然而，裸盖菇素抑制SWA在第一个睡眠周期。没有发现睡眠相关神经可塑性的证据，但是，不同的剂量，时间，对睡眠稳态调节的影响，或与抗抑郁作用相关的其他机制可能起作用。总的来说，这项研究表明裸盖菇素的潜在抗抑郁特性可能与睡眠变化有关。
Serotonergic agonist psilocybin is a psychedelic with antidepressant potential. Sleep may interact with psilocybin’s antidepressant properties like other antidepressant drugs via induction of neuroplasticity. The main aim of the study was to evaluate the effect of psilocybin on sleep architecture on the night after psilocybin administration. Regarding the potential antidepressant properties, we hypothesized that psilocybin, similar to other classical antidepressants, would reduce rapid eye movement (REM) sleep and prolong REM sleep latency. Moreover, we also hypothesized that psilocybin would promote slow-wave activity (SWA) expression in the first sleep cycle, a marker of sleep-related neuroplasticity. Twenty healthy volunteers (10 women, age 28–53) underwent two drug administration sessions, psilocybin or placebo, in a randomized, double-blinded design. Changes in sleep macrostructure, SWA during the first sleep cycle, whole night EEG spectral power across frequencies in non-rapid eye movement (NREM) and REM sleep, and changes in subjective sleep measures were analyzed. The results revealed prolonged REM sleep latency after psilocybin administration and a trend toward a decrease in overall REM sleep duration. No changes in NREM sleep were observed. Psilocybin did not affect EEG power spectra in NREM or REM sleep when examined across the whole night. However, psilocybin suppressed SWA in the first sleep cycle. No evidence was found for sleep-related neuroplasticity, however, a different dosage, timing, effect on homeostatic regulation of sleep, or other mechanisms related to antidepressant effects may play a role. Overall, this study suggests that potential antidepressant properties of psilocybin might be related to changes in sleep.
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影响因子：
--
作者：
Duncan WC Jr;Ballard ED;Zarate CA
通讯作者：
Zarate CA
影响因子：
4.4
作者：
Groeger, JA;Zijlstra, FRH;Dijk, DJ
通讯作者：
Dijk, DJ
影响因子：
3.4
作者：
Barbanoj, Manel J.;Riba, Jordi;Romero, S.
通讯作者：
Romero, S.
DOI：
10.1523/jneurosci.2604-11.2011
发表时间：
2011-12-07
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Andrillon T;Nir Y;Staba RJ;Ferrarelli F;Cirelli C;Tononi G;Fried I
通讯作者：
Fried I
影响因子：
6.6
作者：
Duncan, Wallace C., Jr.;Selter, Jessica;Brutsche, Nancy;Sarasso, Simone;Zarate, Carlos A., Jr.
通讯作者：
Zarate, Carlos A., Jr.