Oxidative Stress and Salvia miltiorrhiza in Aging-Associated Cardiovascular Diseases.
Oxidative Stress and Salvia miltiorrhiza in Aging-Associated Cardiovascular Diseases.
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DOI：
10.1155/2016/4797102
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发表时间：
2016
影响因子：
--
通讯作者：
Hung YC
中科院分区：
文献类型：
--
作者：
Chang CC;Chang YC;Hu WL;Hung YC
衰老相关性心血管疾病（cvd）有一些危险因素与氧化应激密切相关。丹参（Salvia miltiorrhiza， SM）在中国社会被广泛用于治疗心血管疾病已有数百年的历史。我们的目的是探讨SM对衰老相关心血管疾病氧化应激的影响。通过对Medicine、PubMed、EMBASE、Cochrane library、CINAHL、Scopus等数据库的文献检索，我们发现SM不仅具有抗氧化、抗凋亡、抗炎作用，还具有血管生成和心脏保护作用。SM可能通过抑制氧化酶、减少超氧化物的产生、抑制低密度脂蛋白的氧化修饰和改善线粒体氧化应激来减少活性氧的产生。SM还能提高过氧化氢酶、锰超氧化物歧化酶、谷胱甘肽过氧化物酶和偶联内皮型一氧化氮合酶的活性。此外，SM还能减少缺血/再灌注损伤的影响，防止心肌梗死后的心脏纤维化，在冠心病时保持心功能，维持血脑屏障的完整性，促进脑卒中时神经干/祖细胞的自我更新和增殖。然而，未来的临床设计良好和随机对照试验将需要证实SM对衰老相关心血管疾病的疗效。
Aging-associated cardiovascular diseases (CVDs) have some risk factors that are closely related to oxidative stress. Salvia miltiorrhiza (SM) has been used commonly to treat CVDs for hundreds of years in the Chinese community. We aimed to explore the effects of SM on oxidative stress in aging-associated CVDs. Through literature searches using Medicine, PubMed, EMBASE, Cochrane library, CINAHL, and Scopus databases, we found that SM not only possesses antioxidant, antiapoptotic, and anti-inflammatory effects but also exerts angiogenic and cardioprotective activities. SM may reduce the production of reactive oxygen species by inhibiting oxidases, reducing the production of superoxide, inhibiting the oxidative modification of low-density lipoproteins, and ameliorating mitochondrial oxidative stress. SM also increases the activities of catalase, manganese superoxide dismutase, glutathione peroxidase, and coupled endothelial nitric oxide synthase. In addition, SM reduces the impact of ischemia/reperfusion injury, prevents cardiac fibrosis after myocardial infarction, preserves cardiac function in coronary disease, maintains the integrity of the blood-brain barrier, and promotes self-renewal and proliferation of neural stem/progenitor cells in stroke. However, future clinical well-designed and randomized control trials will be necessary to confirm the efficacy of SM in aging-associated CVDs.
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