Alcohol consumption and epigenetic age acceleration across human adulthood.
Alcohol consumption and epigenetic age acceleration across human adulthood.
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DOI：
10.18632/aging.205153
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发表时间：
2023-10-26
期刊：
影响因子：
5.2
通讯作者：
Liu, Chunyu
中科院分区：
文献类型：
--
作者：
Wang, Mengyao;Li, Yi;Lai, Meng;Nannini, Drew R.;Hou, Lifang;Joehanes, Roby;Huan, Tianxiao;Levy, Daniel;Ma, Jiantao;Liu, Chunyu
与酒精相关的生物衰老仍有待研究。我们对3823名弗雷明汉心脏研究参与者（24-92岁，53.8%为女性）进行了线性回归分析，以调查饮酒与两个基于DNA甲基化的生物年龄加速指标之间的关系，并调整了协变量。我们还研究了两种表观遗传衰老指标是否介导了饮酒与高血压的关联。我们发现，较高的长期平均饮酒量与中年（45-64岁，n = 1866）和老年（65-92岁，n = 1267）参与者的GrimAge加速（GAA）和PhenoAge加速（PAA）评估的生物年龄加速显著相关，而在年轻参与者（24-44岁，n = 690）中则没有。例如，在中年和老年参与者中，额外标准饮酒一次（每天约14克乙醇）分别与PAA增加0.71±0.15年（p = 2.1e-6）和0.60±0.18年（p = 7.5e-4）相关，但在年轻参与者中，这种关联并不显著（p = 0.23）。与啤酒（GAA: 0.45年，p = 5.2e-4; PAA: 0.48年，p = 0.02）和葡萄酒（GAA: 0.51年，p = 0.02; PAA: 0.91年，p = 0.008）相比，一份额外的标准酒（~14克乙醇）与GAA（0.82年，p = 4.8e-4）和PAA（1.45年，p = 7.4e-5）的增加有更大的关系。我们观察到，在合并样本中，高达28%的饮酒与高血压之间的关联是由GAA或PAA介导的。我们的研究结果表明，酒精消费与表观遗传衰老指标量化的更大的生物衰老有关，这可能介导酒精消费与定量特征（如高血压）的关联。
The alcohol-associated biological aging remains to be studied across adulthood. We conducted linear regression analyses to investigate the associations between alcohol consumption and two DNA methylation-based biological age acceleration metrics in 3823 Framingham Heart Study participants (24–92 years and 53.8% women) adjusting for covariates. We also investigated whether the two epigenetic aging metrics mediated the association of alcohol consumption with hypertension. We found that higher long-term average alcohol consumption was significantly associated with biological age acceleration assessed by GrimAge acceleration (GAA) and PhenoAge acceleration (PAA) in middle-aged (45–64 years, n = 1866) and older (65–92 years, n = 1267) participants while not in young participants (24–44 years, n = 690). For example, one additional standard drink of alcohol (~14 grams of ethanol per day) was associated with a 0.71 ± 0.15-year (p = 2.1e-6) and 0.60 ± 0.18-year (p = 7.5e-4) increase in PAA in middle-aged and older participants, respectively, but the association was not significant in young participants (p = 0.23). One additional standard serving of liquor (~14 grams of ethanol) was associated with a greater increase in GAA (0.82-year, p = 4.8e-4) and PAA (1.45-year, p = 7.4e-5) than beer (GAA: 0.45-year, p = 5.2e-4; PAA: 0.48-year, p = 0.02) and wine (GAA: 0.51-year, p = 0.02; PAA: 0.91-year, p = 0.008) in middle-aged participant group. We observed that up to 28% of the association between alcohol consumption and hypertension was mediated by GAA or PAA in the pooled sample. Our findings suggest that alcohol consumption is associated with greater biological aging quantified by epigenetic aging metrics, which may mediate the association of alcohol consumption with quantitative traits, such as hypertension.
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影响因子：
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作者：
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