Evaluating the transmission risk of SARS-CoV-2 from sewage pollution.
Evaluating the transmission risk of SARS-CoV-2 from sewage pollution.
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DOI：
10.1016/j.scitotenv.2022.159161
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发表时间：
2023-02-01
影响因子：
9.8
通讯作者：
Savolainen, V.
中科院分区：
文献类型：
--
作者：
Ransome, E.;Hobbs, F.;Jones, S.;Coleman, C. M.;Harris, N. D.;Woodward, G.;Bell, T.;Trew, J.;Kolarevic, S.;Kracun-Kolarevic, M.;Savolainen, V.
许多国家已证实在未经处理的污水中存在SARS-CoV-2，但对其在受污染水域中的发病率和感染风险知之甚少。英国泰晤士河从57个合流下水道溢流(CSO)中接收未经处理的污水，其中许多每年排放数十次。这项研究调查了这种放电是否为SARS-CoV-2的环境传播提供了一条途径。在泰晤士河上收集了近六个民间社会组织的废水、地表水和沉积物样本，在八个月的时间里对SARS-CoV-2RNA和传染性病毒进行了检测。双壳类也被作为病毒生物积累的指示物种进行了采样。来自塞尔维亚多瑙河和萨瓦河的沉积物和水样被检测为阳性对照，这些河流的原始污水也大量排放。在英国的样本中没有发现SARS-CoV-2 RNA或传染性病毒的证据，这与塞尔维亚的RNA阳性样本形成对比。此外，这项研究表明，传染性SARS-CoV-2疫苗在泰晤士河水和沉积物中稳定3天，而SARS-CoV-2 RNA至少在7天内可检测到。这表明废水的稀释可能限制了环境传播，仅检测到病毒RNA并不是病原体溢出的迹象。
The presence of SARS-CoV-2 in untreated sewage has been confirmed in many countries but its incidence and infection risk in contaminated waters is poorly understood. The River Thames in the UK receives untreated sewage from 57 Combined Sewer Overflows (CSOs), with many discharging dozens of times per year. This study investigated if such discharges provide a pathway for environmental transmission of SARS-CoV-2. Samples of wastewater, surface water, and sediment collected close to six CSOs on the River Thames were assayed over eight months for SARS-CoV-2 RNA and infectious virus. Bivalves were also sampled as an indicator species of viral bioaccumulation. Sediment and water samples from the Danube and Sava rivers in Serbia, where raw sewage is also discharged in high volumes, were assayed as a positive control. No evidence of SARS-CoV-2 RNA or infectious virus was found in UK samples, in contrast to RNA positive samples from Serbia. Furthermore, this study shows that infectious SARS-CoV-2 inoculum is stable in Thames water and sediment for <3 days, while SARS-CoV-2 RNA is detectable for at least seven days. This indicates that dilution of wastewater likely limits environmental transmission, and that detection of viral RNA alone is not an indication of pathogen spillover.
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