Morphological and molecular alterations in 1,2 dimethylhydrazine and azoxymethane induced colon carcinogenesis in rats.
Morphological and molecular alterations in 1,2 dimethylhydrazine and azoxymethane induced colon carcinogenesis in rats.
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DOI：
10.1155/2011/473964
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发表时间：
2011
影响因子：
--
通讯作者：
Cerar A
中科院分区：
文献类型：
--
作者：
Perše M;Cerar A
二甲肼（DMH）或氧化偶氮甲烷（AOM）模型是一种成熟的、备受赞赏的和广泛使用的实验性结肠癌发生模型。它与散发性大肠癌在形态学和分子生物学上有许多相似之处，本文就其进行了综述和讨论。此外，本文结合目前的知识，在DMH/AOM大鼠模型中认识到CC的多步发展的形态和分子特征。这种理解是必要的，以准确地识别和解释发生在结肠粘膜的变化时，评价天然或药理化合物在DMH/AOM大鼠结肠癌发生。DMH/AOM模型为研究CC的各种起始和环境因素、特定饮食和遗传因素的作用以及治疗方案提供了广泛的选择。这个模型的局限性和建议的领域，需要更多的研究进行了讨论。
The dimethyhydrazine (DMH) or azoxymethane (AOM) model is a well-established, well-appreciated, and widely used model of experimental colon carcinogenesis. It has many morphological as well as molecular similarities to human sporadic colorectal cancer (CC), which are summarized and discussed in this paper. In addition, the paper combines present knowledge of morphological and molecular features in the multistep development of CC recognized in the DMH/AOM rat model. This understanding is necessary in order to accurately identify and interpret alterations that occur in the colonic mucosa when evaluating natural or pharmacological compounds in DMH/AOM rat colon carcinogenesis. The DMH/AOM model provides a wide range of options for investigating various initiating and environmental factors, the role of specific dietary and genetic factors, and therapeutic options in CC. The limitations of this model and suggested areas in which more research is required are also discussed.
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DOI：
10.1152/ajpgi.2000.278.2.g266
发表时间：
2000-02-01
影响因子：
4.5
作者：
De Jong, TA;Skinner, SA;O'Brien, PE
通讯作者：
O'Brien, PE
影响因子：
29.4
作者：
DuBois, RN;Radhika, A;Entingh, AJ
通讯作者：
Entingh, AJ
影响因子：
9.7
作者：
BIRD, RP
通讯作者：
BIRD, RP
影响因子：
3.5
作者：
Bird, RP;Good, CK
通讯作者：
Good, CK
影响因子：
8.8
作者：
De Filippo, C;Caderni, G;Dolara, P
通讯作者：
Dolara, P