Efficacy of a novel mode of action of an indoor residual spraying product, SumiShield® 50WG against susceptible and resistant populations of Anopheles gambiae (s.l.) in Benin, West Africa.
Efficacy of a novel mode of action of an indoor residual spraying product, SumiShield® 50WG against susceptible and resistant populations of Anopheles gambiae (s.l.) in Benin, West Africa.
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DOI：
10.1186/s13071-018-2869-6
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发表时间：
2018-05-10
影响因子：
3.2
通讯作者：
Akogbeto MC
中科院分区：
文献类型：
--
作者：
Agossa FR;Padonou GG;Koukpo CZ;Zola-Sahossi J;Azondekon R;Akuoko OK;Ahoga J;N'dombidje B;Akinro B;Fassinou AJYH;Sezonlin M;Akogbeto MC
过去十年来，扩大长效驱虫蚊帐的分发和室内滞留喷洒杀虫剂，使撒哈拉以南非洲的疟疾发病率和死亡率大幅下降。由于冈比亚按蚊 (s.s.) 拟除虫菊酯抗药性强度的增加和氨基甲酸酯抗药性的蔓延，以及世界卫生组织推荐用于病媒控制的杀虫剂数量有限，需要具有持久残留活性的 IRS 替代杀虫剂配方，以维持在大多数疟疾流行国家所取得的成果。在贝宁 Covè 的实验小屋中，对住友化学开发的 SumiShield 50WG（噻虫胺 300 mg ai/m2）与溴氰菊酯 25 mg ai/m2（K-Othrine 250 WG）一起针对具有拟除虫菊酯耐药性的冈比亚按蚊 (s.l.) 种群进行了评估。还在锥形生物测定中用易感 An 测试了残留活性。冈比亚“Kisumu”菌株和当地野生抗性种群。结果表明，溴氰菊酯对寻求宿主的抗性按蚊种群的毒性非常低（死亡率在 1-40% 之间）。相比之下，在喷洒后 8 个月的观察期内，SumiShield 在 120 小时观察中的总体平均死亡率为 91.7%。使用锥体测试测得的残留活性在喷洒后24周内抗性野生按蚊种群超过80% WHO阈值，对于易感品系“Kisumu”喷洒后32周内超过80% WHO阈值。在疟疾永久性传播地区以及按蚊种群对拟除虫菊酯等其他传统杀虫剂具有抗药性的地区，SumiShield 是 IRS 的良好候选者。通过评估 SumiShield 50WG 在媒介对杀虫剂具有高度抗药性的地区的社区层面（小规模现场测试）的功效和残留效应来完成实验小屋研究将是很有趣的。
Scale-up of the distribution of long-lasting insecticide-treated bed nets and indoor residual spraying with insecticides over the last decade have contributed to the considerable decrease of malaria morbidity and mortality in sub-Saharan Africa. Due to the increasing pyrethroid resistance intensity and the spread of carbamate resistance in Anopheles gambiae (s.s.) mosquitoes and the limited number of insecticides recommended by the WHO for vector control, alternative insecticide formulations for IRS with long-lasting residual activity are required to sustain the gains obtained in most malaria-endemic countries. SumiShield 50WG (clothianidin 300 mg ai/m2) developed by Sumitomo Chemical was evaluated alongside deltamethrin 25 mg ai/m2 (K-Othrine 250 WG) against a pyrethroid resistant Anopheles gambiae (s.l.) population in experimental huts in Covè, Benin. Residual activity was also tested in cone bioassays with the susceptible An. gambiae “Kisumu” strain and the local wild resistant population. The results showed very low toxicity from deltamethrin (mortality rates ranged between 1–40%) against host-seeking resistant Anopheles populations. SumiShield in contrast gave an overall mean mortality of 91.7% at the 120 h observation across the eight- month observation period following spraying. The residual activity measured using cone tests was over the 80% WHO threshold for 24 weeks for resistant wild Anopheles population and 32 weeks for the susceptible strain “Kisumu” after the spraying. SumiShield is a good candidate for IRS in areas of permanent malaria transmission and where Anopheles populations are resistant to other conventional insecticides such as pyrethroids. It would be interesting to complete experimental huts studies by assessing the efficacy and residual effect of SumiShield 50WG at community level (small-scale field testing) in an area where vectors are highly resistant to insecticides.
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影响因子：
3.2
作者：
Dengela, Dereje;Seyoum, Aklilu;Fornadel, Christen M.
通讯作者：
Fornadel, Christen M.
影响因子：
3
作者：
Akogbeto, Martin C.;Padonou, Gil Germain;Yadouleton, Anges
通讯作者：
Yadouleton, Anges
影响因子：
11.8
作者：
Edi CV;Koudou BG;Jones CM;Weetman D;Ranson H
通讯作者：
Ranson H
影响因子：
3.2
作者：
Aikpon, Rock;Agossa, Fiacre;Akogbeto, Martin
通讯作者：
Akogbeto, Martin
影响因子：
3
作者：
Damien, Georgia B.;Djenontin, Armel;Henry, Marie-Claire
通讯作者：
Henry, Marie-Claire