Multiple-insecticide resistance in Anopheles gambiae mosquitoes, Southern Côte d'Ivoire.
Multiple-insecticide resistance in Anopheles gambiae mosquitoes, Southern Côte d'Ivoire.
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DOI：
10.3201/eid1809.120262
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发表时间：
2012-09
影响因子：
11.8
通讯作者：
Ranson H
中科院分区：
文献类型：
--
作者：
Edi CV;Koudou BG;Jones CM;Weetman D;Ranson H
过去，预防疟疾看起来就像杀死媒介蚊子一样简单；然而，最近的一项研究表明，这个概念现在绝非简单。蚊子对杀虫剂的抗药性正对高效使用经杀虫剂处理的蚊帐和室内喷洒杀虫剂构成挑战。在西非，这种蚊媒的种群现在对批准使用的所有4类杀虫剂都具有抗药性。预计最早也要到2020年才会有新的杀虫剂种类。开发新种类的杀虫剂至关重要，因为如果抗药性继续不受控制，非洲疟疾控制方面来之不易的进展可能很快就会逆转。疟疾控制取决于蚊子对杀虫剂的敏感性。我们测试了科特迪瓦冈比亚按蚊的抗药性，并筛选了目标位点突变的一个子集。蚊子对所有批准类别的杀虫剂都有抗药性。这种完全抗药性，包括异常强烈的表型，对疟疾控制构成了重大威胁。
Preventing malaria used to seem as simple as killing the vector, the mosquito; however, a recent study shows that this concept is now anything but simple. The highly effective use of insecticide-treated bed nets and indoor insecticide spraying is being challenged by mosquito resistance to insecticides. In West Africa, populations of this mosquito vector are now resistant to all 4 classes of insecticide approved for this use. And no new classes of insecticide are anticipated until 2020, at the earliest. Development of newer classes of insecticide is crucial because if resistance continues unchecked, the hard-earned progress in malaria control in Africa could be quickly reversed. Malaria control depends on mosquito susceptibility to insecticides. We tested Anopheles gambiae mosquitoes from Côte d’Ivoire for resistance and screened a subset for target site mutations. Mosquitoes were resistant to insecticides of all approved classes. Such complete resistance, which includes exceptionally strong phenotypes, presents a major threat to malaria control.
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斯里兰卡疟疾按蚊媒介中涉及代谢变化和不敏感靶位点的多种杀虫剂抗性机制。
影响因子：
3
作者：
Perera, M. Devika B.;Hemingway, Janet;Karunaratne, S. H. P. Parakrama
通讯作者：
Karunaratne, S. H. P. Parakrama
影响因子：
1.9
作者：
N'Guessan, R;Darriet, F;Chandre, F
通讯作者：
Chandre, F
影响因子：
3
作者：
Bass, Chris;Nikou, Dimitra;Donnelly, Martin J.;Williamson, Martin S.;Ranson, Hilary;Ball, Amanda;Vontas, John;Field, Linda M.
通讯作者：
Field, Linda M.
影响因子：
3.7
作者：
Yewhalaw D;Wassie F;Steurbaut W;Spanoghe P;Van Bortel W;Denis L;Tessema DA;Getachew Y;Coosemans M;Duchateau L;Speybroeck N
通讯作者：
Speybroeck N
影响因子：
1.9
作者：
Hougard, JM;Corbel, V;Traoré-Lamizana, M
通讯作者：
Traoré-Lamizana, M