Sonographic visualization of nipple blood flow can help differentiate Paget disease from benign eczematous nipple lesions.
Sonographic visualization of nipple blood flow can help differentiate Paget disease from benign eczematous nipple lesions.
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DOI：
10.1371/journal.pone.0197156
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Kaneko H
中科院分区：
文献类型：
--
作者：
Ogata H;Mitsuzuka Y;Honma N;Yoshida M;Sumazaki M;Saito F;Kobayashi M;Shibuya K;Mikami T;Kaneko H
乳房佩吉特病是一种罕见的癌症，起源于乳头乳晕复合体。它经常被忽视和误诊为良性慢性乳头湿疹。我们的目的是回顾性验证是否使用多普勒超声血流分析是有用的检测佩吉特病的存在。在这项回顾性研究中，纳入了12例经病理证实的单侧乳头湿疹性病变患者（7例为佩吉特病，5例为单纯性皮炎）。用多普勒超声观察乳头血流信号，并使用数字记录图像对检测到的血流信号进行定量。定量血流比和病理检查毛细血管密度之间的影响和未受影响的乳头进行了评价。回顾了乳腺X线摄影、灰阶超声和对比增强磁共振成像（CE-MRI）的结果。在佩吉特病患者中，受累乳头的多普勒效应比未受累乳头更清晰可见。这些效应足以识别佩吉特病。对单纯性皮炎患侧和非患侧乳头无明显影响。佩吉特病变的定量血流比率和病理检查的毛细血管密度显著高于非佩吉特病变。CE-MRI和多普勒超声的敏感性显著相关，显示了佩吉特病乳头病变的血流变化。多普勒超声显示佩吉特病变中血管增生。使用多普勒超声检查乳头血流增加的可视化是一种简单且成本低的方法，为在常规医疗护理中识别佩吉特病提供了有用的数据。
Paget disease of the breast is a rare cancer that originates from the nipple–areolar complex. It is often overlooked and misdiagnosed as benign chronic eczema of the nipple. We aimed to retrospectively verify whether blood flow analysis using Doppler sonography was useful for detecting the presence of Paget disease. In this retrospective study, 12 patients with pathologically proven unilateral nipple eczematous lesions (seven with Paget disease and five with simple dermatitis) were included. Nipple blood flow signal was observed using Doppler sonography, and the detected blood flow signals were quantified using digitally recorded images. Quantified blood flow ratio and pathologically examined capillary density were evaluated between affected and unaffected nipples. Findings of mammography, grayscale sonography, and contrast-enhanced magnetic resonance imaging (CE-MRI) were reviewed. In patients with Paget disease, Doppler effects in the affected nipple were more clearly visible than those in the unaffected nipple. These effects were sufficiently visible to identify Paget disease. No obvious effects were observed in the affected and unaffected nipples of simple dermatitis. The quantified blood flow ratio and pathologically examined capillary density were significantly higher for the Paget lesion than those for the non-Paget lesion. The sensitivity of CE-MRI and Doppler sonography was markedly correlated, revealing blood flow changes in the nipple lesions of Paget disease. Doppler sonography visualized the proliferation of blood vessels in Paget lesions. The visualization of increased nipple blood flow using Doppler sonography is a simple and low-cost method that provides useful data for identifying Paget disease during routine medical care.
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影响因子：
5.5
作者：
Burke, ET;Braeuning, MP;Cooper, LL
通讯作者：
Cooper, LL
影响因子：
2.6
作者：
Kim, Hyeon Sook;Seok, Jee Hyun;Seo, Young Jin
通讯作者：
Seo, Young Jin
DOI：
10.1111/j.1440-1673.1995.tb00227.x
发表时间：
1995-02-01
期刊：
Australasian radiology
影响因子：
--
作者：
Rickard, M T;Selopranoto, U S
通讯作者：
Selopranoto, U S
影响因子：
5.5
作者：
Lim, Hyo Soon;Jeong, Su Jin;Kang, Heoung Keun
通讯作者：
Kang, Heoung Keun
影响因子：
6.2
作者：
Kothari, AS;Beechey-Newman, N;Ryder, K
通讯作者：
Ryder, K