Family history of myocardial infarction is an independent risk factor for venous thromboembolism: the Tromsø study
Family history of myocardial infarction is an independent risk factor for venous thromboembolism: the Tromsø study
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心肌梗死家族史是静脉血栓栓塞的独立危险因素：特罗姆瑟研究
DOI：
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发表时间：
2008
影响因子：
10.4
通讯作者：
J. Hansen
中科院分区：
文献类型：
--
作者：
S. Brækkan;E. Mathiesen;I. Njølstad;T. Wilsgaard;J. Størmer;J. Hansen
背景：最近的研究表明动脉性心血管疾病和静脉血栓栓塞（VTE）有共同的危险因素。 心肌梗死（MI）家族史是未来MI的一个强而独立的危险因素。目的：本研究的目的是在一项前瞻性、基于人群的研究中确定心血管风险因素（包括MI家族史）对VTE发生率的影响。 患者和方法：传统的心血管危险因素和MI家族史登记在21 330例受试者，年龄25-96岁，在1994-95年入组的Tromsostatin研究。 随访期间的首次终生VTE事件登记截至2007年9月1日。结果：在平均10.9年的随访期间，有327例VTE事件（1.40/1000人年），138例（42%）为无诱因。 在年龄和性别校正分析中，年龄[每十年的风险比（HR），1.97; 95%置信区间（CI），1.82-2.12]、性别（男性vs.女性; HR，1.25; 95% CI，1.01-1.55）、体重指数（BMI; HR/3 kg m−2，1.21; 95% CI，1.13-1.31）和MI家族史（HR，1.31; 95% CI，1.04-1.65）与VTE显著相关。 在多变量分析中，MI家族史仍然是总VTE（HR，1.27; 95% CI，1.01-1.60）和非诱因VTE（HR，1.46; 95% CI，1.03-2.07）的显著风险因素。血压、总胆固醇、HDL-胆固醇、甘油三酯和吸烟与总VTE无关。结论：MI家族史是MI和VTE的危险因素，并提供了静脉和动脉血栓形成之间联系的进一步证据。
Summary. Background: Recent studies indicate that arterial cardiovascular diseases and venous thromboembolism (VTE) share common risk factors. A family history of myocardial infarction (MI) is a strong and independent risk factor for future MI. Objectives: The purpose of the present study was to determine the impact of cardiovascular risk factors, including family history of MI, on the incidence of VTE in a prospective, population‐based study. Patients and methods: Traditional cardiovascular risk factors and family history of MI were registered in 21 330 subjects, aged 25–96 years, enrolled in the Tromsø study in 1994–95. First‐lifetime VTE events during follow‐up were registered up to 1 September 2007. Results: There were 327 VTE events (1.40 per 1000 person‐years), 138 (42%) unprovoked, during a mean of 10.9 years of follow‐up. In age‐ and gender‐adjusted analysis, age [hazard ratio (HR) per decade, 1.97; 95% confidence interval (CI), 1.82–2.12], gender (men vs. women; HR, 1.25; 95% CI, 1.01–1.55), body mass index (BMI; HR per 3 kg m−2, 1.21; 95% CI, 1.13–1.31), and family history of MI (HR, 1.31; 95% CI, 1.04–1.65) were significantly associated with VTE. Family history of MI remained a significant risk factor for total VTE (HR, 1.27; 95% CI, 1.01–1.60) and unprovoked VTE (HR, 1.46; 95% CI, 1.03–2.07) in multivariable analysis. Blood pressure, total cholesterol, HDL‐cholesterol, triglycerides, and smoking were not independently associated with total VTE. Conclusions: Family history of MI is a risk factor for both MI and VTE, and provides further evidence of a link between venous and arterial thrombosis.
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影响因子：
37.8
作者：
Folsom, AR;Rosamond, WD;Wu, KK
通讯作者：
Wu, KK
影响因子：
5
作者：
Glynn, RJ;Rosner, B
通讯作者：
Rosner, B
影响因子：
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作者：
Silverstein, MD;Heit, JA;Melton, LJ
通讯作者：
Melton, LJ
影响因子：
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作者：
Tsai, AW;Cushman, M;Folsom, AR
通讯作者：
Folsom, AR