Dissecting the mechanisms of Notch induced hyperplasia.
Dissecting the mechanisms of Notch induced hyperplasia.
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DOI：
10.1038/emboj.2012.326
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发表时间：
2013-01-09
期刊：
影响因子：
11.4
通讯作者：
Bray, Sarah J.
中科院分区：
文献类型：
--
作者：
Djiane, Alexandre;Krejci, Alena;Bernard, Frederic;Fexova, Silvie;Millen, Katherine;Bray, Sarah J.
Notch途径对增殖的结果取决于细胞环境，在一些（包括几种癌症）中是生长促进，而在其他癌症中是生长抑制。这种不同的结果在果蝇翅盘中是明显的，其中Notch过度激活导致增生，尽管对增殖具有局部抑制作用。为了了解潜在的机制，我们已经使用基因组策略来识别在翅盘增生期间直接激活的Notch-CSL靶基因。其中包括参与自主和非自主调节增殖，生长和细胞死亡的基因，为以前报道的Notch诱导的翅盘增生的许多特征提供分子解释。Notch目标表现出不同的响应模式，这些模式由Notch目标本身之间的正前馈调节和负前馈调节形成。因此，我们提出，直接Notch靶点的特征及其交叉调节关系在协调增生模式中很重要。
The outcome of the Notch pathway on proliferation depends on cellular context, being growth promotion in some, including several cancers, and growth inhibition in others. Such disparate outcomes are evident in Drosophila wing discs, where Notch overactivation causes hyperplasia despite having localized inhibitory effects on proliferation. To understand the underlying mechanisms, we have used genomic strategies to identify the Notch-CSL target genes directly activated during wing disc hyperplasia. Among them were genes involved in both autonomous and non-autonomous regulation of proliferation, growth and cell death, providing molecular explanations for many characteristics of Notch induced wing disc hyperplasia previously reported. The Notch targets exhibit different response patterns, which are shaped by both positive and negative feed-forward regulation between the Notch targets themselves. We propose, therefore, that both the characteristics of the direct Notch targets and their cross-regulatory relationships are important in coordinating the pattern of hyperplasia.
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影响因子：
1.2
作者：
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通讯作者：
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DOI：
10.1073/pnas.040576497
发表时间：
2000-03-14
影响因子：
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作者：
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通讯作者：
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影响因子：
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