Cadmium exposure and all-cause and cardiovascular mortality in the U.S. general population.
Cadmium exposure and all-cause and cardiovascular mortality in the U.S. general population.
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DOI：
10.1289/ehp.1104352
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发表时间：
2012-07
影响因子：
10.4
通讯作者：
Guallar E
中科院分区：
文献类型：
--
作者：
Tellez-Plaza M;Navas-Acien A;Menke A;Crainiceanu CM;Pastor-Barriuso R;Guallar E
背景：尿液镉浓度与 1988-1994 年美国国家健康和营养检查调查 (NHANES) 人群中男性的全因死亡率和心血管死亡率相关。自 1988 年以来，美国的镉暴露量大幅减少。在最近的暴露水平下，血液和尿液中的镉与心血管疾病 (CVD) 死亡率之间的关系尚不清楚。目的：我们评估了 1999 年至 2004 年美国人口中血液和尿液镉浓度与全因死亡率和 CVD 死亡率的前瞻性关联。方法：我们对 8,989 名 20 岁以上的参与者进行了平均 4.8 年的随访。使用 Cox 回归估计了比较镉分布的第 80 个百分位数和第 20 个百分位数的死亡率终点的风险比。结果：血液和尿液镉的多变量调整风险比 [95% 置信区间 (CI)] 分别为 1.50 (95% CI: 1.07, 2.10) 和 1.52 (95% CI: 1.00, 2.29)，全因死亡率分别为 1.69 (95% CI: 1.03, 2.77) 和 1.74 CVD 死亡率为 1.98 (95% CI: 1.07, 2.83)，心脏病死亡率为 1.98 (95% CI: 1.11, 3.54) 和 2.53 (95% CI: 1.54, 4.16)，心脏病死亡率为 1.73 (95% CI: 0.88, 3.40) 和 2.09 (95% CI: 1.06)。 4.13) 冠心病死亡率。与血液 (0.80 μg/L) 和尿液 (0.57 μg/g) 镉分布的第 80 个百分位相关的人群归因风险，全因死亡率分别为 7.0% 和 8.8%，CVD 死亡率分别为 7.5% 和 9.2% 结论：我们发现了强有力的证据，表明镉在暴露水平相当低的情况下，仍然是全因死亡率的重要决定因素以及美国成年人代表性样本的 CVD 死亡率。进一步减少人群镉暴露的努力可能有助于大幅减少心血管疾病负担。
Background: Urine cadmium concentrations were associated with all-cause and cardiovascular mortality in men in the 1988–1994 U.S. National Health and Nutrition Examination Survey (NHANES) population. Since 1988, cadmium exposure has decreased substantially in the United States. The associations between blood and urine cadmium and cardiovascular disease (CVD) mortality at more recent levels of exposure are unknown. Objectives: We evaluated the prospective association of blood and urine cadmium concentrations with all-cause and CVD mortality in the 1999–2004 U.S. population. Methods: We followed 8,989 participants who were ≥ 20 years of age for an average of 4.8 years. Hazard ratios for mortality end points comparing the 80th to the 20th percentiles of cadmium distributions were estimated using Cox regression. Results: The multivariable adjusted hazard ratios [95% confidence intervals (CIs)] for blood and urine cadmium were 1.50 (95% CI: 1.07, 2.10) and 1.52 (95% CI: 1.00, 2.29), respectively, for all-cause mortality, 1.69 (95% CI: 1.03, 2.77) and 1.74 (95% CI: 1.07, 2.83) for CVD mortality, 1.98 (95% CI: 1.11, 3.54) and 2.53 (95% CI: 1.54, 4.16) for heart disease mortality, and 1.73 (95% CI: 0.88, 3.40) and 2.09 (95% CI: 1.06, 4.13) for coronary heart disease mortality. The population attributable risks associated with the 80th percentile of the blood (0.80 μg/L) and urine (0.57 μg/g) cadmium distributions were 7.0 and 8.8%, respectively, for all-cause mortality and 7.5 and 9.2%, respectively, for CVD mortality Conclusions: We found strongly suggestive evidence that cadmium, at substantially low levels of exposure, remains an important determinant of all-cause and CVD mortality in a representative sample of U.S. adults. Efforts to further reduce cadmium exposure in the population could contribute to a substantial decrease in CVD disease burden.
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影响因子：
10.4
作者：
Nawrot TS;Van Hecke E;Thijs L;Richart T;Kuznetsova T;Jin Y;Vangronsveld J;Roels HA;Staessen JA
通讯作者：
Staessen JA
影响因子：
8.3
作者：
Egwuogu, Heartley;Shendell, Derek G.;Goodfellow, Lynda
通讯作者：
Goodfellow, Lynda
影响因子：
10.4
作者：
Menke A;Muntner P;Silbergeld EK;Platz EA;Guallar E
通讯作者：
Guallar E
DOI：
10.1161/atvbaha.109.190082
发表时间：
2009-09-01
影响因子：
8.7
作者：
Messner, Barbara;Knoflach, Michael;Bernhard, David
通讯作者：
Bernhard, David
影响因子：
3.5
作者：
Maret, Wolfgang
通讯作者：
Maret, Wolfgang