Overexpression of S100A4 is closely associated with the progression and prognosis of gastric cancer in young patients
Overexpression of S100A4 is closely associated with the progression and prognosis of gastric cancer in young patients
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S100A4过表达与青年胃癌进展及预后密切相关
DOI：
10.3892/ol.2013.1220
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发表时间：
2013-02
期刊：
影响因子：
2.9
通讯作者：
TIANHUI WANG
中科院分区：
文献类型：
--
作者：
HUA LI;ZIQUAN LIU;CHUANXIANG XU;YUNYUN CHEN;JIANWEI ZHANG;BO CUI;XUEWEI CHEN;GAIHONG AN;XIAOJUN SHE;HONGTAO LIU;ZIFENG JIANG;TIANHUI WANG
本研究的目的是确定年轻患者胃癌（GC）中S100A4表达与进展、预后和临床病理的相关性。方法 选取2001年1月至2006年12月期间接受手术的年轻GC患者（<40岁）共85个肿瘤组织及其相应的邻近正常组织和62个非转移淋巴结（LN）及其相应的转移淋巴结。通过RT-PCR和免疫组化检测S100A4的表达。在胃癌组织、匹配的正常胃粘膜、非转移性淋巴结和转移性淋巴结中观察到S100A4 mRNA或蛋白表达的差异。胃癌组织和转移性淋巴结中S100A4 mRNA和蛋白的表达量分别显着高于匹配的正常胃粘膜和非转移性淋巴结（P<0.05）。 S100A4的过表达与肿瘤进展和不良预后相关参数显着相关，包括肿瘤大小（P=0.017）、Lauren分类（P=0.002）、组织学分类（P=0.010）、组织学分化（P=0.000）、Borrmann分类（P=0.020）、肿瘤淋巴结转移（TNM）分期（P=0.000）、LN转移（P=0.000）和远处转移（P=0.024）。多变量分析表明患者年龄（P=0.035）、肿瘤大小（P=0.002）、TNM分期（P=0.001）和S100A4上调（P=0.000）是该疾病的独立预后指标。 S100A4在年轻GC患者中的过度表达与临床病理特征显着相关。 S100A4可作为生物标志物来预测年轻GC的进展和不良预后...
.The aim of this study was to determine the correlation of S100A4 expression with the progression, prognosis and clinical pathology of gastric cancer (GC) in young pateints. A total of 85 tumor tissues with corresponding adjacent normal tissues and 62 non‑metastatic lymph nodes (LNs) with corresponding metastatic LNs were obtained from young GC patients (<40 years old) who underwent surgery between January 2001 and December 2006. The expression of S100A4 was detected by RT‑PCR and immunohistochemistry. Differences in the expression of S100A4 mRNA or protein were observed among the GC tissues, matched normal gastric mucosa, non‑metastatic LNs and metastatic LNs. The expression of S100A4 mRNA and protein in GC tissues and metastatic LNs was significantly higher compared with that in the matched normal gastric mucosa and non‑metastatic LNs, respectively (P<0.05). The overexpression of S100A4 was significantly associated with parameters involved in tumor progression and poor prognosis, including tumor size (P=0.017), Lauren classification (P=0.002), histological classification (P=0.010), histological differentiation (P=0.000), Borrmann classification (P=0.020), tumor‑node‑metastasis (TNM) stage (P=0.000), LN metastasis (P=0.000) and distant metastasis (P=0.024). Multivariate analysis suggested that patient age (P=0.035), tumor size (P=0.002), TNM stage (P=0.001) and S100A4 upregulation (P=0.000) were independent prognostic indicators for the disease. The overexpression of S100A4 in young GC patients is significantly associated with the clinicopathological characteristics. S100A4 maybe used as a biomarker to predict the progression and poor prognosis of GC in young...
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影响因子：
--
作者：
Chin-Yau Chen;Chew-Wen Wu;S. Lo;M. Hsieh;W. Lui;K. Shen
通讯作者：
Chin-Yau Chen;Chew-Wen Wu;S. Lo;M. Hsieh;W. Lui;K. Shen
影响因子：
2.1
作者：
Matsumoto, Kazumasa;Irie, Akira;Baba, Shiro
通讯作者：
Baba, Shiro
影响因子：
4.8
作者：
Lee, Ok-Jae;Hong, Seung-Mo;El-Rifai, Wael
通讯作者：
El-Rifai, Wael
影响因子：
10.3
作者：
Sack, Ulrike;Walther, Wolfgang;Stein, Ulrike
通讯作者：
Stein, Ulrike
DOI：
--
发表时间：
2000-11
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Y. Yonemura;Y. Endou;K. Kimura;S. Fushida;E. Bandou;K. Taniguchi;K. Kinoshita;I. Ninomiya;K. Sugiyama;C. Heizmann;B. Schafer;Takuma Sasaki
通讯作者：
Y. Yonemura;Y. Endou;K. Kimura;S. Fushida;E. Bandou;K. Taniguchi;K. Kinoshita;I. Ninomiya;K. Sugiyama;C. Heizmann;B. Schafer;Takuma Sasaki