Conjugated linoleic acid and calcium co-supplementation improves bone health in ovariectomised mice.
Conjugated linoleic acid and calcium co-supplementation improves bone health in ovariectomised mice.
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DOI：
10.1016/j.foodchem.2012.12.067
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发表时间：
2013-09-01
期刊：
影响因子：
8.8
通讯作者：
Park, Yeonhwa
中科院分区：
文献类型：
--
作者：
Park, Yooheon;Kim, Jonggun;Scrimgeour, Angus G.;Condlin, Michelle L.;Kim, Daeyoung;Park, Yeonhwa
骨质疏松症是老年人的一个重要健康问题;共轭亚油酸（CLA）已被证明可以改善整体骨量，当钙作为共同补充剂时。然而，在骨丢失期间CLA和钙对骨量的潜在影响尚未报道。本研究的目的是确定膳食钙如何调节共轭亚油酸（CLA）在预防骨丢失的作用，使用卵巢切除小鼠模型。与未补充CLA的对照组相比，补充CLA可显著预防卵巢切除相关的体重和脂肪量增加。CLA显着增加骨标志物，而在股骨骨矿物质组成的重大变化相比，各自的控制。CLA治疗显著增加血清甲状旁腺激素（PTH）（p = 0.0172），而血清1，25-二羟维生素D3浓度没有改变CLA。同时，CLA显着降低股骨抗酒石酸酸性磷酸酶（TRAP）的活性，表明潜在的减少破骨细胞的生成。这些数据表明，共轭亚油酸，沿着膳食钙，有很大的潜力被用来防止骨质流失和体重增加与更年期。
Osteoporosis is a significant health concern for the elderly; conjugated linoleic acid (CLA) has been shown to improve overall bone mass when calcium is included as a co-supplement. However, potential effects of CLA and calcium on bone mass during a period of bone loss have not been reported. The purpose of this study was to determine how dietary calcium modulates the effects of conjugated linoleic acid (CLA) in preventing bone loss, using an ovariectomised mouse model. CLA supplementation significantly prevented ovariectomy-associated weight and fat mass gain, compared to non-supplemented controls. CLA significantly increased bone markers without major changes in bone mineral composition in the femur compared to respective controls. CLA treatment increased serum parathyroid hormone (PTH) significantly (p = 0.0172), while serum 1,25-dihydroxyvitamin D3 concentration was not changed by CLA. Meanwhile, CLA significantly reduced femur tartrate resistant acid phosphatase (TRAP) activity, suggesting potential reduction of osteoclastogenesis. The data suggest that CLA, along with dietary calcium, has great potential to be used to prevent bone loss and weight gain associated with menopause.
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DOI：
10.1016/j.plefa.2004.10.015
发表时间：
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影响因子：
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